Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Naphthaleneaceticacid, 6-methoxy-a-methyl-,(aR)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

23979-41-1

23979-41-1 structure

23979-41-1 structure

Name: (R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
Chemical Name: (r)-naproxen
CAS Number: 23979-41-1
Molecular Formula: C₁₄H₁₄O₃
Molecular Weight: 230.259
Catalog: Research Areas Cancer
Create Date: 2018-09-12 11:04:34
Modify Date: 2026-07-01 17:54:49
l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3].

Name	(r)-naproxen
Synonyms	Naproxen Impurity G Einecs -6 piproxen (R)-Naproxen, 10 mM in DMSO (+)-(S)-Naproxen (R)-Naproxen Naproxen Impurity G (Naproxen Related Compound G, (R)-Naproxen) (R)-2-(6-Methoxy-2-naphthyl)propionic acid (R)-2-(2-methoxynaphthalen-6-yl)propanoic acid Naproxen Impurity G (R-Naproxen) Naproxen (2R)-2-(6-Methoxynaphth-2-yl)propanoic acid (R)-α-Methyl-6-methoxynaphthalene-2-acetic acid Naproxen RC G Naproxen Impurity G/ Naproxen Related Compound G (Naproxen R-Isomer) (+)-NAPROXEN ALEVE (R)-NAPROXEN (S)-naproxen Naproxen R-Isomer Naproxen Related Compound G Anaprox NAPRELAN (2S)-2-(6-Methoxynaphth-2-yl)propanoic acid (2R)-2-(6-methoxy-2-naphthyl)propanoic acid 2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, (αR) (R)-()-6-Methoxy-α-methyl-2-naphthaleneacetic acid (S)-(+)-Naproxen (2R)-2-(6-Methoxynaphthalen-2-yl)propanoic Acid ((R)-Naproxen) (R)-6-METHOXY-A-METHYL-2-NAPHTHALENEACETIC ACID (R)-α-Methyl-6-methoxy-2-naphthaleneacetic acid MFCD00870716 (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid (2R)-2-(6-Methoxy-2-naphthyl)propanoic acid (r)-(-)-6-methoxy-α-methyl-2-naphthaleneacetic acid 2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, (R)- (8CI) (2S)-2-(6-Methoxy-2-naphthyl)propanoic acid (R)-(-)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID Apronax EINECS 245-966-6 (R)-Naproxen, (2R)-2-(6-Methoxynaphth-2-yl)propionic acid, 2-[(1R)-1-Cboxyethyl]-6-methoxynaphthalene (S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid l-Naproxen (Naproxen Impurity) Naproxen Impurity 7（Naproxen Impurity G） (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid ((R)-enantiomer) 3-(4-chlorophenyl)-2-cyclohexyloxaziridine 2-Naphthaleneacetic acid, 6-methoxy-a-methyl-, - (9CI) (R)-6-methoxy-alpha-methylnaphthalene-1-acetic acid (R)-(-)-6-METHOXY-ALPHA-METHYL-2-NAPHTH& Naprosyn

Description	l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in cells[3]. l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3]. l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3]. Cell Viability Assay[3] Cell Line: HeLa cells Concentration: 30-1000 μM Incubation Time: 2 hour Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively. Cell Migration Assay [3] Cell Line: OvCa429 and OvCa433 cells Concentration: 0-300 μM Incubation Time: 48 hour Result: Had a statistically significant inhibitory effect at 300 μM compared to untreated controls. Western Blot Analysis[3] Cell Line: OvCa433 cells Concentration: 300 μM Incubation Time: 48 hour Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls.
References	[1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780. [2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103. [3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182.

Density	1.2±0.1 g/cm3
Boiling Point	403.9±20.0 °C at 760 mmHg
Melting Point	156-158ºC(lit.)
Molecular Formula	C₁₄H₁₄O₃
Molecular Weight	230.259
Flash Point	154.5±15.3 °C
Exact Mass	230.094299
PSA	46.53000
LogP	3.00
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.609
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S36/S37
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3.0
HS Code	2918990090

Precursor 9
27602-79-5 880872-42-4 81623-44-1 31220-35-6
63444-51-9 5111-65-9 107951-72-4 201230-82-2
30012-51-2
DownStream 2
81623-44-1 26159-35-3

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.