(R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid

Modify Date: 2025-08-24 09:21:27

(R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid structure	Common Name	(R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
	CAS Number	23979-41-1	Molecular Weight	230.259
	Density	1.2±0.1 g/cm3	Boiling Point	403.9±20.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₄O₃	Melting Point	156-158ºC(lit.)
	MSDS	Chinese USA	Flash Point	154.5±15.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of (R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid

l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3].

Name	(r)-naproxen
Synonym	More Synonyms

Description	l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in cells[3]. l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3]. l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3]. Cell Viability Assay[3] Cell Line: HeLa cells Concentration: 30-1000 μM Incubation Time: 2 hour Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively. Cell Migration Assay [3] Cell Line: OvCa429 and OvCa433 cells Concentration: 0-300 μM Incubation Time: 48 hour Result: Had a statistically significant inhibitory effect at 300 μM compared to untreated controls. Western Blot Analysis[3] Cell Line: OvCa433 cells Concentration: 300 μM Incubation Time: 48 hour Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls.
References	[1]. Sonika Batra, et al. Enantiomeric Resolution of (RS)-Naproxen and Application of (S)- Naproxen in the Direct and Indirect Enantioseparation of Racemic Compounds by Liquid Chromatography: A Review. Curr Med Chem. 2017;24(8):758-780. [2]. M Iwaki, et al. Stereoselective disposition of naproxen glucuronide in the rat. Drug Metab Dispos. 1995 Oct;23(10):1099-103. [3]. Tudor I Oprea, et al. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. PLoS One. 2015 Nov 11;10(11):e0142182.

Density	1.2±0.1 g/cm3
Boiling Point	403.9±20.0 °C at 760 mmHg
Melting Point	156-158ºC(lit.)
Molecular Formula	C₁₄H₁₄O₃
Molecular Weight	230.259
Flash Point	154.5±15.3 °C
Exact Mass	230.094299
PSA	46.53000
LogP	3.00
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.609
InChIKey	CMWTZPSULFXXJA-SECBINFHSA-N
SMILES	COc1ccc2cc(C(C)C(=O)O)ccc2c1
Storage condition	2-8°C

MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S36/S37
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3.0
HS Code	2918990090

Precursor 9
CAS#:27602-79-5 Dehydronaproxen CAS#:880872-42-4 (R)-naproxen salt CAS#:81623-44-1 (R)-6-methoxy-α... CAS#:31220-35-6 ethyl (2S)-2-(6...
CAS#:63444-51-9 2-Methoxy-6-vin... CAS#:5111-65-9 2-Bromo-6-metho... CAS#:107951-72-4 2-(((2S,4S)-4-h... CAS#:201230-82-2 carbon monoxide
CAS#:30012-51-2 Methyl 2-(6-met...
DownStream 2
CAS#:81623-44-1 (R)-6-methoxy-α... CAS#:26159-35-3 (S)-Naproxen Me...

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Name: Selectivity ratio of IC50 for inhibition of COX1 in ram seminal vesicles to IC50 for ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4428996

Name: Selectivity ratio of IC50 for COX2 (unknown origin) to IC50 for human recombinant AKR...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4428997

Name: Binding affinity to human DHFR at 5 mM in presence of MFM by NMR spectroscopy
Source: ChEMBL
Target: Dihydrofolate reductase
External Id: CHEMBL4621661

Name: Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: ORF 73 [Human herpesvirus 8 type M]
External Id: HMS791

Name: Inhibition of human recombinant AKR1C3 using S-tetralol as substrate assessed as redu...
Source: ChEMBL
Target: Aldo-keto reductase family 1 member C3
External Id: CHEMBL4428988

Name: Inhibition of human recombinant AKR1C2 using S-tetralol as substrate assessed as redu...
Source: ChEMBL
Target: Aldo-keto reductase family 1 member C2
External Id: CHEMBL4428989

Name: Selectivity ratio of IC50 for human recombinant AKR1C2 to IC50 for human recombinant ...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4428990

Name: S-Tetralol Oxidation Assay from US Patent US11459295: "2-beta-naphthyl-acetic acid an...
Source: BindingDB
Target: N/A
External Id: BindingDB_10852_1

Name: Contractile Force Screening of Prestwick Library for asthma drug discovery
Source: 24015
Target: N/A
External Id: HSPH_Screening_CFS_001

Name: Inhibition of COX1 in ram seminal vesicles using arachidonic acid as substrate assess...
Source: ChEMBL
Target: Prostaglandin G/H synthase 1
External Id: CHEMBL4428992

Total 11, Current Page 1 of 2

piproxen

(+)-(S)-Naproxen

Anaprox

(R)-Naproxen

MFCD00870716

(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid

(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid

NAPRELAN

(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid

(2S)-2-(6-Methoxynaphth-2-yl)propanoic acid

Naproxen

Apronax

EINECS 245-966-6

(+)-NAPROXEN

(S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid

(S)-(+)-Naproxen

ALEVE

(S)-naproxen

Naprosyn

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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Naphthaleneaceticacid, 6-methoxy-a-methyl-,(aR)-
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China
Product Name: (R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid
Price: ￥136.0/250mg ￥1736.0/10g ￥1036.0/5g ￥346.0/1g
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
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(R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid

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