(R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid structure
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Common Name | (R)-2-(6-Methoxynaphthalen-2-yl)propanoic acid | ||
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CAS Number | 23979-41-1 | Molecular Weight | 230.259 | |
Density | 1.2±0.1 g/cm3 | Boiling Point | 403.9±20.0 °C at 760 mmHg | |
Molecular Formula | C14H14O3 | Melting Point | 156-158ºC(lit.) | |
MSDS | Chinese USA | Flash Point | 154.5±15.3 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of (R)-2-(6-Methoxynaphthalen-2-yl)propanoic acidl-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3]. |
Name | (r)-naproxen |
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Synonym | More Synonyms |
Description | l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibit Cdc42 and Rac1 (EC50=96 μM and 212 μM, respectively), and show anti-tumor activity[1][2][3]. |
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Related Catalog | |
In Vitro | l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in cells[3]. l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3]. l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3]. Cell Viability Assay[3] Cell Line: HeLa cells Concentration: 30-1000 μM Incubation Time: 2 hour Result: Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50 values of 212 μM and 96 μM, respectively. Cell Migration Assay [3] Cell Line: OvCa429 and OvCa433 cells Concentration: 0-300 μM Incubation Time: 48 hour Result: Had a statistically significant inhibitory effect at 300 μM compared to untreated controls. Western Blot Analysis[3] Cell Line: OvCa433 cells Concentration: 300 μM Incubation Time: 48 hour Result: Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls. |
References |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 403.9±20.0 °C at 760 mmHg |
Melting Point | 156-158ºC(lit.) |
Molecular Formula | C14H14O3 |
Molecular Weight | 230.259 |
Flash Point | 154.5±15.3 °C |
Exact Mass | 230.094299 |
PSA | 46.53000 |
LogP | 3.00 |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.609 |
Storage condition | 2-8°C |
Precursor 9 | |
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DownStream 2 | |
HS Code | 2918990090 |
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Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
piproxen |
2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, (αR)- |
(+)-(S)-Naproxen |
Anaprox |
(R)-Naproxen |
2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, (αS)- |
MFCD00870716 |
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid |
(2R)-2-(6-Methoxy-2-naphthyl)propanoic acid |
NAPRELAN |
(2S)-2-(6-Methoxy-2-naphthyl)propanoic acid |
2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, (S)- |
(2S)-2-(6-Methoxynaphth-2-yl)propanoic acid |
2-naphthaleneacetic acid, 6-methoxy-a-methyl-, (aS)- |
Naproxen |
Apronax |
EINECS 245-966-6 |
(+)-NAPROXEN |
(S)-(+)-6-methoxy-α-methyl-2-naphthaleneacetic acid |
(S)-(+)-Naproxen |
ALEVE |
(S)-naproxen |
Naprosyn |