5714-73-8

• 常用中文名：马尿酸乌洛托品
• 常用英文名：Methenamine hippurate
• CAS号：5714-73-8
• 分子式：C₁₅H₂₁N₅O₃
• 分子量：319.35900
• 相关类别： 原料药 人工合成抗感染类药 硝基呋喃类药
• 发布时间：2018-03-01 08:00:00
• 更新时间：2024-01-05 18:24:07
• Methenamine hippurate (Hexamine hippurate) 是一种口服活性尿液抗菌剂,具有广泛的抗菌谱。Methenamine hippurate 对大多数常见的尿路病原体有效。

名称

• 中文名: 马尿酸乌洛托品
• 英文名: Hiprex
• 英文别名: Hippramine; Hexamethylenetetramine hippurate; R-657; Haiprex; Hexamethylenetetramine monohippurate; Viapta; hexamine hippurate; Methenamine hippurate

物化性质

• 沸点: 464.1ºC at 760mmHg
• 熔点: 89-95ºC
• 分子式: C₁₅H₂₁N₅O₃
• 分子量: 319.35900
• 闪点: 234.5ºC
• 精确质量: 319.16400
• PSA: 79.36000
• 外观性状: 白色结晶粉末
• 储存条件: Refrigerator

生物活性

• 描述: Methenamine hippurate (Hexamine hippurate) 是一种口服活性尿液抗菌剂,具有广泛的抗菌谱。Methenamine hippurate 对大多数常见的尿路病原体有效。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 马尿酸甲酯是一种尿中释放甲醛并排泄在尿液中的抗菌剂。马尿酸甲胺在pH 5～6的体外对大肠杆菌、金黄色葡萄球菌、空气杆菌、铜绿假单胞菌和普通变形杆菌有明显的抑制作用,对肺炎克雷伯菌、铜绿假单胞菌、大肠杆菌、葡萄球菌有广泛的抑制作用。pH值为7.4的金黄色葡萄球菌和溶血性链球菌。这种作用比单独使用甲基苯丙胺、单独使用马尿酸或使用磺胺嘧啶[1]更有效。
• 参考文献:

  [1]. Forbes R, et al. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial. Trials. 2018;19(1):616. Published 2018 Nov 9.

  [2]. Gibson GR. A clinical appraisal of methenamine hippurate in urinary tract infections. Med J Aust. 1970;1(4):167‐170.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : MR8159000 CAS REGISTRY NUMBER : 5714-73-8 LAST UPDATED : 199504 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C9-H9-N-O3.C6-H12-N4 MOLECULAR WEIGHT : 319.41 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2870 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 16,328,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82903 No. of Facilities: 14 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 504 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82903 No. of Facilities: 16 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) No. of Female Employees: 62 (estimated)

安全

• 危害码 (欧洲): Xi
• 危险品运输编码: NONH for all modes of transport