6500-81-8

6500-81-8 structure

Name: Ethacrynic acid sodium
Chemical Name: sodium,2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetate
CAS Number: 6500-81-8
Molecular Formula: C₁₃H₁₁Cl₂NaO₄
Molecular Weight: 325.12
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2016-08-22 03:25:47
Modify Date: 2026-07-14 16:59:44
Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

Name	sodium,2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetate
Synonyms	ethacrynic acid sodium Edecrin Sodium Sodium ethacrynate Sodium edecrin Acetic acid, 2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy-, sodium salt Ethacrynate sodium (USP) UNII-K41MYV7MPM [2,3-Dichloro-4-(2-methylenebutyryl)phenyloxy]acetic acid sodium salt ethacrynic acid, sodium salt ETHACRYNATE SODIUM Ethacrynate Acetic acid,(2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)-,sodium salt

Description	Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase Research Areas >> Inflammation/Immunology
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Hazard Codes	Xi