1226781-44-7
1226781-44-7 structure
- Name: Omarigliptin
- Chemical Name: Omarigliptin
- CAS Number: 1226781-44-7
- Molecular Formula: C17H20F2N4O3S
- Molecular Weight: 398.427
- Catalog: Biochemical Inhibitor Proteases DPP-4 inhibitor
- Create Date: 2018-04-04 08:00:00
- Modify Date: 2026-06-30 13:31:54
-
Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over allproteases tested (IC50 > 67 μM).IC50 value: 1.6 nM [1]Target: DPP-4 inhibitorin vitro: Omarigliptin has weak ion channel activity (IC50 > 30 μM at IKr, Cav1.2, and Nav1.5). An expansive selectivity counterscreen (168 radioligand binding or enzymatic assays) was carried out at MDS Pharma. An IC50 > 10 μM was obtained in all assays. in vivo: When orally administered 1 h prior to dextrose challenge in an oral glucose tolerance test (OGTT), it significantly reduced blood glucose excursion in a dose-dependent manner from 0.01 mg/kg (7% reduction in glucose AUC) to 0.3 mg/kg (51% reduction).
| Name | Omarigliptin |
|---|---|
| Synonyms |
MK-3012
Omigliptin, 10 mM in DMSO Omigliptin（1226-7） Oralliptin 2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine MK3102 2H-Pyran-3-amine, 2-(2,5-difluorophenyl)-5-[2,6-dihydro-2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-, (2R,3S,5R) MK-3102, Omigliptin [USAN], Omigliptin (USAN/INN), SureCN827590, UNII-CVP59Q4JE1, CHEMBL2105762, MK-3102, PB39113 (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-(methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)te Omigliptin (MK-3102)Q: What is Omigliptin (MK-3102) Q: What is the CAS Number of Omigliptin (MK-3102) Q: What is the storage condition of Omigliptin (MK-3102) (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-methylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine MK-3102 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine MK-3102, >= MK-3102 Omigliptin a potent, selective and long-acting DPP-4 inhibitor OMigliptin OMigliptin (MK-3102) (2S,3R,5S)-2-(2,5-Difluorophenyl)-5-[2-(Methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-aMine (MK-3102 enantioMer) MK 3102:MK-3102 UNII-CVP59Q4JE1 (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-tetrahydro-2H-pyran-3-amine (2R,3S,5R)-2-(2,5-DIFLUOROPHENYL)- 5-[2-(METHYLSULFONYL)-2,6- DIHYDROPYRROLO[3,4-C]PYRAZOL-5(4H)- YL (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(2-(Methylsulfonyl)pyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)tetrahydro-2H-pyran-3-aMine Ogliptin (2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine MK-3102;MK3102;MK MK-3102 - M10588 MK-3102(OMIGLIPTIN) |
| Description | Omarigliptin(MK-3102) is a potent, selective and long-acting DPP-4 inhibitor with IC50 of 1.6 nM; highly selective over allproteases tested (IC50 > 67 μM).IC50 value: 1.6 nM [1]Target: DPP-4 inhibitorin vitro: Omarigliptin has weak ion channel activity (IC50 > 30 μM at IKr, Cav1.2, and Nav1.5). An expansive selectivity counterscreen (168 radioligand binding or enzymatic assays) was carried out at MDS Pharma. An IC50 > 10 μM was obtained in all assays. in vivo: When orally administered 1 h prior to dextrose challenge in an oral glucose tolerance test (OGTT), it significantly reduced blood glucose excursion in a dose-dependent manner from 0.01 mg/kg (7% reduction in glucose AUC) to 0.3 mg/kg (51% reduction). |
|---|---|
| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.4±60.0 °C at 760 mmHg |
| Molecular Formula | C17H20F2N4O3S |
| Molecular Weight | 398.427 |
| Flash Point | 274.0±32.9 °C |
| Exact Mass | 398.122406 |
| PSA | 98.83000 |
| LogP | 0.46 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.689 |
| Storage condition | -20℃ |
| Precursor 5 | |
|---|---|
| DownStream 0 | |