128837-71-8

128837-71-8 structure

Name: PKSI-527
Chemical Name: 2-[4-[[(2S)-2-[[4-(aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]acetic acid,hydrochloride
CAS Number: 128837-71-8
Molecular Formula: C₂₅H₃₂ClN₃O₄
Molecular Weight: 473.99
Catalog: Signaling Pathways Metabolic Enzyme/Protease Ser/Thr Protease
Create Date: 2017-03-29 14:38:05
Modify Date: 2024-01-31 12:10:31
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1].

Name	2-[4-[[(2S)-2-[[4-(aminomethyl)cyclohexanecarbonyl]amino]-3-phenylpropanoyl]amino]phenyl]acetic acid,hydrochloride
Synonyms	H-Tra-L-Phe-4-carboxymethylanilide hydrochloride Pksi 527 PKSI-0527 C25H31N3O4.HCl t-AMCHA-Phe-p-APAA

Description	PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Ser/Thr Protease Research Areas >> Inflammation/Immunology
References	[1]. Fujimori Y, et al. Effects of a highly selective plasma kallikrein inhibitor on collagen-induced arthritis in mice. Agents Actions. 1993 May;39(1-2):42-8.