72957-42-7

72957-42-7 structure

Name: AMP PNP
Chemical Name: tetralithium,[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
CAS Number: 72957-42-7
Molecular Formula: C₁₀H₁₃Li₄N₆O₁₂P₃
Molecular Weight: 529.92900
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-03-26 08:00:00
Modify Date: 2024-01-12 07:26:26
AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels[1][2].

Name	tetralithium,[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-(phosphonatoamino)phosphinate
Synonyms	tetralithium Adenylyl imidodiphosphate tetralithium salt MFCD03424105 adenylyl-imidodiphosphate tetralithium AMP-PNP EINECS 277-127-5

Description	AMP-PNP tetralithium (Adenylyl-imidodiphosphate tetralithium) is a non-hydrolysable analogue of ATP and inhibits KATP channels[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vitro	AMP-PNP (5 to 500 μM; Li salt) reduced the open-probability po of KATP channels and decreases the single-channel currents at high nucleotide concentrations by approximately 10%[2]. AMP-PNP inhibits KATP channels of ventricular myocytes and of pancreatic β-cells both in the absence and presence of Mg2+ ions[2].
References	[1]. I M Rybakowska, et al. Activities of purine converting enzymes in heart, liver and kidney mice LDLR-/- and Apo E-/. Nucleosides Nucleotides Nucleic Acids. 2018;37(6):340-347. [2]. S Hehl, et al. KATP channels of mouse skeletal muscle: mechanism of channel blockage by AMP-PNP. Eur Biophys J. 1994;23(4):231-7.

Safety Phrases	S22-S24/25