KRM-III

Modify Date: 2024-01-15 12:59:13

KRM-III Structure
KRM-III structure
 Common Name KRM-III
CAS Number 79220-94-3 Molecular Weight 252.33400
Density N/A Boiling Point N/A
Molecular Formula C15H12N2S Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of KRM-III


KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].

 Names

Name 3,5-diphenyl-1H-imidazole-2-thione
Synonym More Synonyms

 KRM-III Biological Activity

Description KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1].
Related Catalog
References

[1]. Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13.

 Chemical & Physical Properties

Molecular Formula C15H12N2S
Molecular Weight 252.33400
Exact Mass 252.07200
PSA 56.62000
LogP 3.82800

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H319
Precautionary Statements P305 + P351 + P338
RIDADR NONH for all modes of transport

 Synonyms

1,4-diphenyl-1H-imidazole-2-thiol
KRM-III
1,4-phenyl-1H-imidazole-2-thiol
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Chemsrc provides KRM-III(CAS#:79220-94-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of KRM-III are included as well.>> amp version: KRM-III

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