342808-40-6

342808-40-6 structure

Name: EF24
Chemical Name: (3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one,hydrochloride
CAS Number: 342808-40-6
Molecular Formula: C₁₉H₁₆ClF₂NO
Molecular Weight: 347.78600
Catalog: Signaling Pathways Apoptosis Caspase
Create Date: 2016-10-09 06:37:51
Modify Date: 2024-01-05 19:10:19
EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].

Name	(3Z,5Z)-3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one,hydrochloride
Synonyms	EF-24 (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone

Description	EF24 is a curcumin analogue with greater anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 treatment increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> ERK
References	[1]. Lelli D, et al. Curcumin and treatment of melanoma: The potential role of microRNAs. Biomed Pharmacother. 2017 Apr;88:832-834. [2]. Mosley CA, et al. Highly active anticancer curcumin analogues. Adv Exp Med Biol. 2007;595:77-103.