125722-16-9

125722-16-9 structure

Name: 2,6-dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol
Chemical Name: 4-[2-(4-fluorophenyl)ethenyl]-2,6-dimethylphenol
CAS Number: 125722-16-9
Molecular Formula: C₁₆H₁₅FO
Molecular Weight: 242.28800
Catalog: Signaling Pathways GPCR/G Protein Leukotriene Receptor
Create Date: 2016-07-20 09:48:39
Modify Date: 2024-01-31 10:46:08
Enofelast (BI-L-239), a 5-lipoxygenase (5-LO) inhibitor, exhibits an IC50 of 2.48 μM for inhibition of calcium ionophore-induced LTB4 generation[1].

Name	4-[2-(4-fluorophenyl)ethenyl]-2,6-dimethylphenol
Synonyms	2,6-Dimethyl-4-(2-(4-fluorophenyl)ethenyl)phenol

Description	Enofelast (BI-L-239), a 5-lipoxygenase (5-LO) inhibitor, exhibits an IC50 of 2.48 μM for inhibition of calcium ionophore-induced LTB4 generation[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	IC50: 2.48 μM (LTB4)[1].
References	[1]. T C Noonan, et al. Effect of BI-L-239, A-64077 and MK-886 on leukotriene B4 synthesis by chopped guinea pig lung and on antigen-induced tracheal contraction in vitro. Prostaglandins. 1992 Dec;44(6):543-54.