219793-45-0
219793-45-0 structure
- Name: BTB06584
- Chemical Name: 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate
- CAS Number: 219793-45-0
- Molecular Formula: C19H12ClNO6S
- Molecular Weight: 417.820
- Catalog: Biochemical Inhibitor Transmembrane Transporters ATPase inhibitor
- Create Date: 2017-07-21 05:03:38
- Modify Date: 2024-01-03 07:02:03
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BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.Target: ATPasein vitro: BTB06584 inhibits F1Fo-ATPase activity with no effect on ΔΨm or O2 consumption. ATP consumption was decreased following inhibition of respiration, and ischaemic cell death was reduced. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein. BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1Fo-ATPsynthase.in vivo: BTB06584 rescues defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.
| Name | 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate |
|---|---|
| Synonyms |
AHAS inhibitor
2-Nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate Benzoic acid, 4-chloro-, 2-nitro-5-(phenylsulfonyl)phenyl ester BTB06584 |
| Description | BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.Target: ATPasein vitro: BTB06584 inhibits F1Fo-ATPase activity with no effect on ΔΨm or O2 consumption. ATP consumption was decreased following inhibition of respiration, and ischaemic cell death was reduced. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein. BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1Fo-ATPsynthase.in vivo: BTB06584 rescues defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 664.8±55.0 °C at 760 mmHg |
| Molecular Formula | C19H12ClNO6S |
| Molecular Weight | 417.820 |
| Flash Point | 355.9±31.5 °C |
| Exact Mass | 417.007385 |
| PSA | 114.64000 |
| LogP | 5.23 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.637 |
| Storage condition | -20℃ |
| Symbol |
GHS05 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H318 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |