BTB06584

Modify Date: 2024-01-03 07:02:03

BTB06584 Structure
BTB06584 structure
Common Name BTB06584
CAS Number 219793-45-0 Molecular Weight 417.820
Density 1.5±0.1 g/cm3 Boiling Point 664.8±55.0 °C at 760 mmHg
Molecular Formula C19H12ClNO6S Melting Point N/A
MSDS Chinese USA Flash Point 355.9±31.5 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of BTB06584


BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.Target: ATPasein vitro: BTB06584 inhibits F1Fo-ATPase activity with no effect on ΔΨm or O2 consumption. ATP consumption was decreased following inhibition of respiration, and ischaemic cell death was reduced. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein. BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1Fo-ATPsynthase.in vivo: BTB06584 rescues defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.

 Names

Name 2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate
Synonym More Synonyms

 BTB06584 Biological Activity

Description BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase.Target: ATPasein vitro: BTB06584 inhibits F1Fo-ATPase activity with no effect on ΔΨm or O2 consumption. ATP consumption was decreased following inhibition of respiration, and ischaemic cell death was reduced. BTB06584 efficiency was increased by IF1 overexpression and reduced by silencing the protein. BTB06584 may represent a valuable tool to selectively inhibit mitochondrial F1Fo-ATPase activity without compromising ATP synthesis and to limit ischaemia-induced injury caused by reversal of the mitochondrial F1Fo-ATPsynthase.in vivo: BTB06584 rescues defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants in which expression of the Atpif1a gene is lost.
Related Catalog
References

[1]. Ivanes F, et al. The compound BTB06584 is an IF1 -dependent selective inhibitor of the mitochondrial F1 Fo-ATPase. Br J Pharmacol. 2014 Sep;171(18):4193-4206.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 664.8±55.0 °C at 760 mmHg
Molecular Formula C19H12ClNO6S
Molecular Weight 417.820
Flash Point 355.9±31.5 °C
Exact Mass 417.007385
PSA 114.64000
LogP 5.23
Vapour Pressure 0.0±2.0 mmHg at 25°C
Index of Refraction 1.637
Storage condition -20℃

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338
RIDADR NONH for all modes of transport

 Synonyms

AHAS inhibitor
2-Nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate
Benzoic acid, 4-chloro-, 2-nitro-5-(phenylsulfonyl)phenyl ester
BTB06584
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