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56-92-8

56-92-8 structure
56-92-8 structure
Name Histamine dihydrochloride
Synonyms 1H-imidazole-5-ethanamine, hydrochloride (1:2)
2-(1H-Imidazol-4-yl)ethylamine dihydrochloride
2-(1H-imidazol-4-yl)ethan-1-amine dihydrochloride
HISTAMINEHYDROCHLORIDE
Ceplene
Histamine dihydrochloride
2-(1H-Imidazol-4-yl)ethanamine dihydrochloride
1H-Imidazole-4-ethanamine, hydrochloride (1:2)
MFCD00012703
histamine*2HCl
1H-Imidazole-4-ethanamine dihydrochloride
hystamine dihydrochloride
HISTAMINE DIHCL
EINECS 200-298-4
histaMine (HCl)2
histaminedichloride
2-(1H-imidazol-4-yl)ethanamine hydrochloride
Density 1.14 g/cm3
Boiling Point 331ºC at 760 mmHg
Melting Point 249-252 °C(lit.)
Molecular Formula C5H11Cl2N3
Molecular Weight 184.067
Flash Point 180.3ºC
Exact Mass 183.033005
PSA 54.70000
LogP 2.21520
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility SOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MS1575000
CHEMICAL NAME :
Histamine, dihydrochloride
CAS REGISTRY NUMBER :
56-92-8
LAST UPDATED :
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C5-H9-N3.2Cl-H
MOLECULAR WEIGHT :
184.09
WISWESSER LINE NOTATION :
T5M CNJ D2Z &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1550 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
REFERENCE :
ACPMAP Actualites Pharmacologiques. (Paris, France) No.1-33, 1949-81. For publisher information, see JNPHAG. Volume(issue)/page/year: 24,51,1971
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>28 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - tremor Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year: 25,503,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2534 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 2,371,1979
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
184 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,1117,1977
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1300 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 166,437,1932
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
370 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 2,371,1979
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - corneal damage Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
REFERENCE :
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 42,473,1928
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4602 ug/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiolar constriction
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 77,54,1943
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
1250 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 8,339,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
290 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 5,2118,1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
570 ug/kg
TOXIC EFFECTS :
Vascular - shock
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 211,328,1950 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2400 mg/kg
SEX/DURATION :
female 1-6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 6,179,1963
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Danger
Hazard Statements H315-H317-H319-H334-H335
Precautionary Statements P261-P280-P305 + P351 + P338-P342 + P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R42
Safety Phrases S22-S26-S36/37/39-S45-S37
RIDADR 3335
WGK Germany 2
RTECS MS1575000
HS Code 2933290090
74294-62-5 structure

74294-62-5

~%

56-92-8 structure

56-92-8

Literature: Battersby; Nicoletti; Staunton; Vleggaar Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 43 - 51
872-82-2 structure

872-82-2

~%

56-92-8 structure

56-92-8

Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 1, p. 43 - 51
55-36-7 structure

55-36-7

~%

56-92-8 structure

56-92-8

Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 1, p. 43 - 51
74294-60-3 structure

74294-60-3

~%

56-92-8 structure

56-92-8

Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 1, p. 43 - 51
HS Code 2933290090
Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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