Histamine dihydrochloride
Histamine dihydrochloride structure
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Common Name | Histamine dihydrochloride | ||
|---|---|---|---|---|
| CAS Number | 56-92-8 | Molecular Weight | 184.067 | |
| Density | 1.14 g/cm3 | Boiling Point | 331ºC at 760 mmHg | |
| Molecular Formula | C5H11Cl2N3 | Melting Point | 249-252 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 180.3ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Histamine dihydrochloride |
|---|---|
| Synonym | More Synonyms |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.14 g/cm3 |
|---|---|
| Boiling Point | 331ºC at 760 mmHg |
| Melting Point | 249-252 °C(lit.) |
| Molecular Formula | C5H11Cl2N3 |
| Molecular Weight | 184.067 |
| Flash Point | 180.3ºC |
| Exact Mass | 183.033005 |
| PSA | 54.70000 |
| LogP | 2.21520 |
| InChIKey | IVCJGQQPPHYHBS-UHFFFAOYSA-N |
| SMILES | Cl.NCCc1cnc[nH]1 |
| Storage condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility | SOLUBLE |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H315-H317-H319-H334-H335 |
| Precautionary Statements | P261-P280-P305 + P351 + P338-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R42 |
| Safety Phrases | S22-S26-S36/37/39-S45-S37 |
| RIDADR | 3335 |
| WGK Germany | 2 |
| RTECS | MS1575000 |
| HS Code | 2933290090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~%
Histamine dihyd... CAS#:56-92-8 |
| Literature: Battersby; Nicoletti; Staunton; Vleggaar Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 1, p. 43 - 51 |
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~%
Histamine dihyd... CAS#:56-92-8 |
| Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 1, p. 43 - 51 |
|
~%
Histamine dihyd... CAS#:56-92-8 |
| Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 1, p. 43 - 51 |
|
~%
Histamine dihyd... CAS#:56-92-8 |
| Literature: Journal of the Chemical Society. Perkin transactions 1, , vol. 1, p. 43 - 51 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 4 | |
|---|---|
| DownStream 7 | |
CAS#:51-45-6![imidazo-[1,5-c]-tetrahydropyrimidin-5-on structure](https://image.chemsrc.com/caspic/358/14509-66-1.png)
CAS#:14509-66-1![4-pyridin-4-yl-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine structure](https://image.chemsrc.com/caspic/148/7271-08-1.png)
CAS#:7271-08-1![4-PYRIDIN-3-YL-4,5,6,7-TETRAHYDRO-3H-IMIDAZO[4,5-C]PYRIDINE structure](https://image.chemsrc.com/caspic/378/876708-23-5.png)
CAS#:876708-23-5![(3-methylphenyl)-[8-[3-(trifluoromethyl)phenyl]sulfonyl-1-thia-4,8-diazaspiro[4.5]decan-4-yl]methanone structure](https://image.chemsrc.com/caspic/024/5959-80-8.png)
CAS#:5959-80-8
CAS#:6429-10-3
CAS#:791634-10-1This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Histamine inhibits differentiation of skin fibroblasts into myofibroblasts.
Biochem. Biophys. Res. Commun. 463 , 434-9, (2015) Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechan... |
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Involvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.
Microcirculation 22 , 237-48, (2015) The mechanisms by which histamine increases microvascular permeability remain poorly understood. We tested the hypothesis that H1 receptor activation disrupts the endothelial barrier and investigated ... |
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New procedure of selected biogenic amines determination in wine samples by HPLC.
Anal. Chim. Acta 834 , 58-66, (2014) A new procedure for determination of biogenic amines (BA): histamine, phenethylamine, tyramine and tryptamine, based on the derivatization reaction with 2-chloro-1,3-dinitro-5-(trifluoromethyl)-benzen... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Thermal Shift Assay. Domain: start/stop: M1-L298
Source: ChEMBL
Target: Cyclin-dependent kinase 2
External Id: CHEMBL5062802
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Thermal Shift Assay. Domain: start/stop: G861-E979
Source: ChEMBL
Target: Transcription intermediary factor 1-alpha
External Id: CHEMBL5069198
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Thermal Shift Assay. Domain: start/stop: N44-E168
Source: ChEMBL
Target: Bromodomain-containing protein 4
External Id: CHEMBL5061766
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Name: Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay
Source: 24386
Target: N/A
External Id: Sarm1 Tir NADase inhibitors screen
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Thermal Shift Assay. Domain: start/stop: M26-R383
Source: ChEMBL
Target: Glycogen synthase kinase-3 beta
External Id: CHEMBL5065589
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Name: Thermal Shift Assay. Domain: start/stop: S229-K512
Source: ChEMBL
Target: Tyrosine-protein kinase ABL1
External Id: CHEMBL5060015
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1H-imidazole-5-ethanamine, hydrochloride (1:2) |
| 2-(1H-Imidazol-4-yl)ethylamine dihydrochloride |
| 2-(1H-imidazol-4-yl)ethan-1-amine dihydrochloride |
| HISTAMINEHYDROCHLORIDE |
| Ceplene |
| Histamine dihydrochloride |
| 2-(1H-Imidazol-4-yl)ethanamine dihydrochloride |
| 1H-Imidazole-4-ethanamine, hydrochloride (1:2) |
| MFCD00012703 |
| histamine*2HCl |
| 1H-Imidazole-4-ethanamine dihydrochloride |
| hystamine dihydrochloride |
| HISTAMINE DIHCL |
| EINECS 200-298-4 |
| histaMine (HCl)2 |
| histaminedichloride |
| 2-(1H-imidazol-4-yl)ethanamine hydrochloride |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of Histamine dihydrochloride? |
| A: Molecular weight of Histamine dihydrochloride is 184.067. |
| Q: What is the English name of Histamine dihydrochloride? |
| A: The English name of Histamine dihydrochloride is Histamine dihydrochloride. |
| Q: What is the SMILES notation of Histamine dihydrochloride? |
| A: SMILES notation of Histamine dihydrochloride is Cl.NCCc1cnc[nH]1. |
| Q: What is the CAS number of Histamine dihydrochloride? |
| A: CAS number of Histamine dihydrochloride is 56-92-8. |
| Q: What are the upstream materials of Histamine dihydrochloride? |
| A: Related upstream materials(CAS) of Histamine dihydrochloride: 74294-62-5;872-82-2;55-36-7;74294-60-3. |
| Q: What is the polar surface area (PSA) of Histamine dihydrochloride? |
| A: Polar surface area (PSA) of Histamine dihydrochloride is 54.70000. |
| Q: How is the water solubility of Histamine dihydrochloride? |
| A: Water solubility of Histamine dihydrochloride: SOLUBLE. |
| Q: What is the molecular formula of Histamine dihydrochloride? |
| A: Molecular formula of Histamine dihydrochloride is C5H11Cl2N3. |
| Q: What are the storage conditions for Histamine dihydrochloride? |
| A: Storage conditions for Histamine dihydrochloride: 2-8°C. |
| Q: What are the downstream products of Histamine dihydrochloride? |
| A: Related downstream products(CAS) of Histamine dihydrochloride: 51-45-6;14509-66-1;7271-08-1;876708-23-5;5959-80-8;6429-10-3;791634-10-1. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |