467-55-0

467-55-0 structure

Name: Hecogenin
Chemical Name: Hecogenin
CAS Number: 467-55-0
Molecular Formula: C₂₇H₄₂O₄
Molecular Weight: 430.620
Catalog: Biochemical Plant extracts
Create Date: 2018-04-23 08:00:00
Modify Date: 2024-01-02 10:20:04
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

Name	Hecogenin
Synonyms	5ALPHA-SPIROSTAN-3BETA-OL-12-ONE 5α-Spirostan-12-one, 3β-hydroxy-, (25R)- (25R)-5-Spirostan-3-ol-12-one MFCD00067285 (22R,25R)-3β-Hydroxy-5α-spirostan-12-one Spirostan-12-one, 3-hydroxy-, (3β,5α,25R)- 12-Oxotigogenin (3β,5α,25R)-3-Hydroxyspirostan-12-one Hocogenin Hecoginin (25R)-3b-Hydroxy-5a-spirostan-12-one Hecogenin EINECS 207-392-4 3-b-Hydroxy-5-a-spirostan-12-one (3,5,25R)-3-Hydroxysiprostan-1 (3,5,25R)-3-Hydroxysiprostan-12-one (3b,5a,25R)-3-Hydroxyspirostan-12-one

Description	Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
Target	Human UDP-glucuronosyltransferases[1]
In Vivo	Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1]. Animal Model: Male Swiss mice (20-30 g) with ethanol[1] Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration: Oral administration; for 15 hours Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
References	[1]. Santos Cerqueira G, et al. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol. 2012 May 15;683(1-3):260-9.

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
WGK Germany	3