Hecogenin

Modify Date: 2024-01-02 10:20:04

Hecogenin structure	Common Name	Hecogenin
	CAS Number	467-55-0	Molecular Weight	430.620
	Density	1.2±0.1 g/cm3	Boiling Point	548.9±50.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₂O₄	Melting Point	268°C
	MSDS	N/A	Flash Point	177.8±23.6 °C

Use of Hecogenin

Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].

Name	Hecogenin
Synonym	More Synonyms

Description	Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Others >> Others
Target	Human UDP-glucuronosyltransferases[1]
In Vivo	Hecogenin (3.1-90 mg/kg; oral administration; for 15 hours; male Swiss mice) acutely administered, before ethanol, exhibits a potent gastroprotective effect. The Hecogenin pretreatment normalizes GSH levels and significantly reduces lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Hecogenin also decreases MPO release and significantly protects the gastric mucosa[1]. Animal Model: Male Swiss mice (20-30 g) with ethanol[1] Dosage: 3.1 mg/kg, 7.5 mg/kg, 15 mg/kg, 30 mg/kg, 60 mg/kg and 90 mg/kg Administration: Oral administration; for 15 hours Result: Normalized GSH levels and significantly reduced lipid peroxidation and nitrite levels in the stomach, as evaluated by the ethanol-induced gastric lesion model. Decreased MPO release and significantly protected the gastric mucosa.
References	[1]. Santos Cerqueira G, et al. Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice. Eur J Pharmacol. 2012 May 15;683(1-3):260-9.

Density	1.2±0.1 g/cm3
Boiling Point	548.9±50.0 °C at 760 mmHg
Melting Point	268°C
Molecular Formula	C₂₇H₄₂O₄
Molecular Weight	430.620
Flash Point	177.8±23.6 °C
Exact Mass	430.308319
PSA	55.76000
LogP	4.22
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.559

Hecogenin MSDS(Chinese)

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
WGK Germany	3

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