76420-72-9

76420-72-9 structure

Name: Enalaprilat
Chemical Name: enalaprilat (anhydrous)
CAS Number: 76420-72-9
Molecular Formula: C₁₈H₂₄N₂O₅
Molecular Weight: 348.39400
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-02-05 08:00:00
Modify Date: 2024-01-02 09:13:01
Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].

Name	enalaprilat (anhydrous)
Synonyms	Vasotec IV MFCD08060099 ENALAPRILAT HYDRATE L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S) S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline ENALAPRILAT USP(CRM STANDARD) Enalaprilat Enalapril acid Enalaprilic Acid 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline enalaprilate Enalapril diacid EINECS 278-459-3

Description	Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 1.94 nM (ACE)[1]
In Vitro	Enalaprilat (1 nM-10 μM; 24 h) attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM[2].
In Vivo	Enalaprilat (0.01%-2.9% in the eyedrop solution) shows significant intraocular pressure (IOP)-lowering effect in rabbits[3].
References	[1]. Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [2]. Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6. [3]. Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41.

Hazard Codes	Xn
Risk Phrases	R68:Possible risk of irreversible effects.
Safety Phrases	S22-S36/37/39
RTECS	DU9085000
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%