Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Enalaprilat
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Purity: 98.0%
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76420-72-9

76420-72-9 structure

Name: Enalaprilat
Chemical Name: enalaprilat (anhydrous)
CAS Number: 76420-72-9
Molecular Formula: C₁₈H₂₄N₂O₅
Molecular Weight: 348.39400
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-02-05 08:00:00
Modify Date: 2026-07-03 09:14:54
Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].

Name	enalaprilat (anhydrous)
Synonyms	L-Proline, N-[(1S)-1-cboxy-3-phenylpropyl]-L-alanyl MFCD08060099 (2S)-1-[(2S)-2-[[(1S)-1-Cboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-cboxylic Acid (Enalap ENALAPRILAT HYDRATE Enalapril maleate impurity C N-[(1S)-1-Cboxy-3-phenylpropyl]-L-alanyl-L-proline Enalaprilat (Enalapril Impurity C) L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S) Enalaprilat(Enalapril IMpurity C) ENALAPRILAT USP(CRM STANDARD) Enalapril acid (S)-1-((S)-2-(((S)-1-Cboxy-3-phenylpropyl)amino)propanoyl)pyrrolidine-2-cboxylic acid Enalaprilic Acid 1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline N-[1(S)-Cboxy-3-phenylpropyl]-L-alanyl-L-proline EINECS 278-459-3 MK 421 diacid L-Proline, 1-[N-(1-cboxy-3-phenylpropyl)-L-alanyl]-, (S) Vasotec IV (2S)-1-[(2S)-2-[[(1S)-1-Cboxy-3-p (2S)-1-[(2S)-2-[[(1S)-1-Cboxy-3-phenylpropyl]amino]propanoyl]pyrrolidine-2-cboxylic Acid (Enalaprilat) ENALAPRILAT (CRM STANDD) N-[(1S)-1-(Cboxy)-3-phenylpropyl]-L-alanyl]-L-proline Dihydrate EnalaprilatQ: What is Enalaprilat Q: What is the CAS Number of Enalaprilat Q: What is the storage condition of Enalaprilat Q: What e the applications of Enalaprilat S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline (2S)-1-[(2S)-2-{[(2R)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]pyrrolidine-2-cboxylic acid Enalaprilat DISCONTINUED. Please see E555375 1-[N-[(S)-1-Cboxy-3-phenylpropyl]-L-alanyl]-L-proline (2S)-1-[(2S)-2-[[(1S)-1-Cboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-cboxylic acid Enalaprilat //BP N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline enalaprilate Enalapril diacid

Description	Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 1.94 nM (ACE)[1]
In Vitro	Enalaprilat (1 nM-10 μM; 24 h) attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM[2].
In Vivo	Enalaprilat (0.01%-2.9% in the eyedrop solution) shows significant intraocular pressure (IOP)-lowering effect in rabbits[3].
References	[1]. Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [2]. Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6. [3]. Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41.

Density	1.286 g/cm3 (20ºC)
Boiling Point	601ºC at 760 mmHg
Melting Point	148-151°C
Molecular Formula	C₁₈H₂₄N₂O₅
Molecular Weight	348.39400
Flash Point	317.3ºC
Exact Mass	348.16900
PSA	106.94000
LogP	1.45490

Hazard Codes	Xn
Risk Phrases	R68:Possible risk of irreversible effects.
Safety Phrases	S22-S36/37/39
RTECS	DU9085000
HS Code	2933990090

Precursor 10
75847-73-3 76095-16-4 104-53-0 120379-81-9
121842-76-0 121842-77-1 121842-75-9 84793-24-8
147-85-3 108428-39-3
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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