Enalaprilat

Modify Date: 2025-08-27 09:48:27

Enalaprilat structure	Common Name	Enalaprilat
	CAS Number	76420-72-9	Molecular Weight	348.39400
	Density	1.286 g/cm3 (20ºC)	Boiling Point	601ºC at 760 mmHg
	Molecular Formula	C₁₈H₂₄N₂O₅	Melting Point	148-151°C
	MSDS	Chinese USA	Flash Point	317.3ºC

Use of Enalaprilat

Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].

Name	enalaprilat (anhydrous)
Synonym	More Synonyms

Description	Enalaprilat (MK-422 anhydrous), the active metabolite of the oral prodrug Enalapril, is a potent, competitive and long-acting angiotensin-converting enzyme (ACE) inhibitor, with an IC50 of 1.94 nM. Enalaprilat can be used for the research of hypertension[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	IC50: 1.94 nM (ACE)[1]
In Vitro	Enalaprilat (1 nM-10 μM; 24 h) attenuates the IGF-I induced neonatal rat cardiac fibroblast growth (30% reduction) in a concentration-dependent fashion, with an IC50 of 90 mM[2].
In Vivo	Enalaprilat (0.01%-2.9% in the eyedrop solution) shows significant intraocular pressure (IOP)-lowering effect in rabbits[3].
References	[1]. Ceconi C, et, al. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6. [2]. Eickels M, et, al. Angiotensin-converting enzyme (ACE) inhibition attenuates insulin-like growth factor-I (IGF-I) induced cardiac fibroblast proliferation. Br J Pharmacol. 2000 Dec;131(8):1592-6. [3]. Loftsson T, et, al. Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits. Acta Ophthalmol. 2010 May;88(3):337-41.

Density	1.286 g/cm3 (20ºC)
Boiling Point	601ºC at 760 mmHg
Melting Point	148-151°C
Molecular Formula	C₁₈H₂₄N₂O₅
Molecular Weight	348.39400
Flash Point	317.3ºC
Exact Mass	348.16900
PSA	106.94000
LogP	1.45490
InChIKey	LZFZMUMEGBBDTC-QEJZJMRPSA-N
SMILES	CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1CCCC1C(=O)O

Hazard Codes	Xn
Risk Phrases	R68:Possible risk of irreversible effects.
Safety Phrases	S22-S36/37/39
RTECS	DU9085000
HS Code	2933990090

Precursor 10
CAS#:75847-73-3 Enalapril CAS#:76095-16-4 Enalapril maleate CAS#:104-53-0 3-Phenylpropanal CAS#:120379-81-9 5-phenylethyl-i...
CAS#:121842-76-0 (R)-2-bromo-4-p... CAS#:121842-77-1 (R)-ethyl 2-bro... CAS#:121842-75-9 N-carbamyl (R)-... CAS#:84793-24-8 Ethyl (S)-2-[(S...
CAS#:147-85-3 Proline CAS#:108428-39-3 Enalapril tert-...
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: pKa (acid-base dissociation constant) as determined by Avdeef ref: DOI: 10.1002/04714...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2449007

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: TP_TRANSPORTER: uptake in Oatp1-expressing HeLa cells
Source: ChEMBL
Target: Solute carrier organic anion transporter family member 1A1
External Id: CHEMBL2077837

Name: Concentration required for 50% inhibition of rabbit lung Angiotensin I converting enz...
Source: ChEMBL
Target: Angiotensin-converting enzyme
External Id: CHEMBL648934

Name: In vitro inhibition of Angiotensin I converting enzyme in rabbit lung
Source: ChEMBL
Target: Angiotensin-converting enzyme
External Id: CHEMBL648935

Name: % Inhibition of angiotensin-I induced pressor response in normotensive rats after int...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL782886

Name: % Inhibition of angiotensin-I induced pressor response in normotensive rats after int...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL782887

Name: % Inhibition of angiotensin-I induced pressor response in normotensive rats after int...
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL783639

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Vasotec IV

MFCD08060099

ENALAPRILAT HYDRATE

L-Proline,1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-,(S)

S-1-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]-L-proline

ENALAPRILAT USP(CRM STANDARD)

Enalaprilat

Enalapril acid

Enalaprilic Acid

1-[N-[(S)-1-Carboxy-3-phenylpropyl]-L-alanyl]-L-proline

N-(1(S)-carboxy-3-phenylpropyl)-L-alanyl-L-proline

enalaprilate

Enalapril diacid

EINECS 278-459-3

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.