BioBioPha
China
Product Name: Cephalomannine
Price: ￥Inquiry/5mg
Purity: 97.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Cephalomannine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

naturewill
China
Product Name: Cephalomannine
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Bella
Email: 3157321941@qq.com

71610-00-9

71610-00-9 structure

Name: Cephalomannine
Chemical Name: Cephalomannine
CAS Number: 71610-00-9
Molecular Formula: C₄₅H₅₃NO₁₄
Molecular Weight: 831.901
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-10-02 11:23:47
Modify Date: 2026-07-01 19:22:46
Cephalomannine is a taxol derivative with antitumor, antiproliferative properties. IC50 value:Target: Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most commonly used to treat non-small cell lung cancer.

Name	Cephalomannine
Synonyms	ChaloMannine, froM Taxus chinensis Chalomannine CAS Paclitaxel Impurity 2（Paclitaxel Impurity B） (2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methyl-2-butenoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate N-Debenzoyl-N-tigloylpaclitaxel (Ce CEPHALOMANNINE:BENZENEPROPANOICACID,-HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX... caphalomannine Paclitaxel Related Compound A (20 mg) (Ce-phalomannine) Taxus Extract Chalomannine Paclitaxel Impurity B benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2,4S,4aS,6R,9S,11S,12S,12,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS) Paclitaxel hringine (2,4S,4aS,6R,9S,11S,12S,12,12bS)-12-(Benzoyloxy)-4,11-dihydroxy-9-(((2R,3S)-2-hydroxy-3-((E)-2-methylbut-2-enamido)-3-phenylpropanoyl)oxy)-4a,8,13,13-tetramethyl-5-oxo-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)-diyl diacetate Paclitaxel Related CoMpound A (2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate Paclitaxel Imp. B : N-debenzoyl-N-tigloylpaclitaxel (chalomannine) Paclitaxel Impurity B/Chalomannine (αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]amino]benzenepropanoic Acid (2,4S,4aS,6R,9S,11S,12S,12,12bS)-6,12b-bis(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester 3'-N-(trans-2-methyl-2-butenoyl)-3'-N-debenzoylpaclitaxel Chalomannine from Taxus chinensis (Pilg.) Rehder CHALOMANNINE (TAXOL B) 4,10β-bis(acetyloxy)-1,7β-dihydroxy-13α-[[(2R,3S)-2-hydroxy-3-[[(2E)-2-methylbut-2-enoyl]amino]-3-phenylpropanoyl]oxy]-9-oxo-5β,20-oxytax-11-en-2α-ylbenzoate(N-debenzoyl-N-tigloylpaclitaxel benzenepropanOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2 N-Debenzoyl-N-tigloylpaclitaxel Chalomannine //BP TAXOL B CEPHALOMANNINE:BENZENEPROPANOICACID,-HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1 CEPHALOMANNINE (TAXOL B) Paclitaxel Impurity B N-debenzoyl-N-tigloylpaclitaxel (chalomannine) 3′-N-(trans-2-methyl-2-butenoyl)-3′-N-debenzoylpaclitaxel Paclitaxel Chalomannine CHALOMANNINE(P) CHALOMANNINE ChalomannineQ: What is Chalomannine Q: What is the CAS Number of Chalomannine Q: What is the storage condition of Chalomannine Q: What e the applications of Chalomannine Paclitaxel Related Compound A CHALOMANNINE:benzenepropanOICACID, -HYDROXY-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX Paclitaxel Impurity Ⅰ:Chalomannine 4-(acetyloxy)-10β,13α-bis[[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy]-1,7β-dihydroxy-9-oxo-5β,20-oxytax-11-en-2α-ylbenzoate(10-O-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]-10-O-deacetylpaclitaxel) Chalomannine 71-9 benzenepropanoicacid, α-hydroxy-β Sanjian Shanning alkaloid benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2,4S,4aS,6R,9S,11S,12S,12,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester chephalomannine Chalomannine, 10 mM in DMSO benzenepropanOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2-[2A,4,4A,6,9[R,S(E)],11,12,12A,12B]] N-debenzoyl-N-tigloylpaclitaxel (chalomannine) paclitaxel iMpurity I (2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate CHALOMANNINE:benzenepropanOICACID, -HYDROXY-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1 Paclitaxel Related Compound A (Chalomannine) [(2-methyl-1-oxo-2-butenyl)amino]-,6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-ylester,[2-[2aα,4β,4aβ,6β,9α[αR,βS(E)],11α,12α,12aα,12bα]] CEPHALOMANNINE(P)

Description	Cephalomannine is a taxol derivative with antitumor, antiproliferative properties. IC50 value:Target: Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most commonly used to treat non-small cell lung cancer.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin Natural Products >> Terpenoids and Glycosides Research Areas >> Cancer
References	[1]. T. Grobosch, B. Schwarze, D. Stoecklein et al. Fatal poisoning with Taxus baccata. Quantification of Paclitaxel (taxol A), 10-Deacetyltaxol, Baccatin III, 10-Deacetylbaccatin III, Cephalomannine (taxol B), and 3,5-Dimethoxyphenol in Body Fluids by Liquid [2]. Jing Zhang et al., Simultaneous Determination of 10-Deacetylbaccatin，Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC. Applied Mechanics and Materials. 2011, 108, 326. [3]. Chang Z, Guo N, Liu T, et al. Distribution and variation of paclitaxel and cephalomannine contents in wild Taxus cuspidata. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(3):294-8. [4]. R Matesanz, J Rodríguez-Salarichs, B Pera, et al. Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes. Biophysical Journal, 2011,101(12): 2970-2980. [5]. Elena Riva, Martin Mattarella, Stella Borrelli, et al. Preparation of Fluorescent Tubulin Binders. ChemPlusChem. Early View (Online Version of Record published before inclusion in an issue)

Density	1.4±0.1 g/cm3
Boiling Point	929.5±65.0 °C at 760 mmHg
Melting Point	139-141ºC
Molecular Formula	C₄₅H₅₃NO₁₄
Molecular Weight	831.901
Flash Point	516.0±34.3 °C
Exact Mass	831.346619
PSA	221.29000
LogP	6.59
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.615
Storage condition	-20°C Freezer
Water Solubility	DMSO: 14 mg/mL, soluble

Symbol	GHS05, GHS07
Signal Word	Danger
Hazard Statements	H315-H318-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	37/38-41
Safety Phrases	26-39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932999022