Cephalomannine

Modify Date: 2024-01-02 06:27:32

Cephalomannine Structure
Cephalomannine structure
 Common Name Cephalomannine
CAS Number 71610-00-9 Molecular Weight 831.901
Density 1.4±0.1 g/cm3 Boiling Point 929.5±65.0 °C at 760 mmHg
Molecular Formula C45H53NO14 Melting Point 139-141ºC
MSDS Chinese USA Flash Point 516.0±34.3 °C
Symbol GHS05 GHS07
GHS05, GHS07		 Signal Word Danger

 Use of Cephalomannine


Cephalomannine is a taxol derivative with antitumor, antiproliferative properties. IC50 value:Target: Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most commonly used to treat non-small cell lung cancer.

 Names

Name Cephalomannine
Synonym More Synonyms

 Cephalomannine Biological Activity

Description Cephalomannine is a taxol derivative with antitumor, antiproliferative properties. IC50 value:Target: Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most commonly used to treat non-small cell lung cancer.
Related Catalog
References

[1]. T. Grobosch, B. Schwarze, D. Stoecklein et al. Fatal poisoning with Taxus baccata. Quantification of Paclitaxel (taxol A), 10-Deacetyltaxol, Baccatin III, 10-Deacetylbaccatin III, Cephalomannine (taxol B), and 3,5-Dimethoxyphenol in Body Fluids by Liquid

[2]. Jing Zhang et al., Simultaneous Determination of 10-Deacetylbaccatin，Cephalomannine and Taxol in Different Parts of Taxus Media with Different Growth Years by UPLC. Applied Mechanics and Materials. 2011, 108, 326.

[3]. Chang Z, Guo N, Liu T, et al. Distribution and variation of paclitaxel and cephalomannine contents in wild Taxus cuspidata. Zhongguo Zhong Yao Za Zhi. 2011 Feb;36(3):294-8.

[4]. R Matesanz, J Rodríguez-Salarichs, B Pera, et al. Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes. Biophysical Journal, 2011,101(12): 2970-2980.

[5]. Elena Riva, Martin Mattarella, Stella Borrelli, et al. Preparation of Fluorescent Tubulin Binders. ChemPlusChem. Early View (Online Version of Record published before inclusion in an issue)

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 929.5±65.0 °C at 760 mmHg
Melting Point 139-141ºC
Molecular Formula C45H53NO14
Molecular Weight 831.901
Flash Point 516.0±34.3 °C
Exact Mass 831.346619
PSA 221.29000
LogP 6.59
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.615
Storage condition -20°C Freezer
Water Solubility DMSO: 14 mg/mL, soluble

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H315-H318-H335
Precautionary Statements P261-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases 37/38-41
Safety Phrases 26-39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2932999022

 Customs

HS Code 2932999022

 Articles26

More Articles
Determination of paclitaxel and related taxanes in bulk drug and injectable dosage forms by reversed phase liquid chromatography.

Anal. Chem. 69(11) , 2008-16, (1997)

Baseline separation of 15 taxanes including paclitaxel (Taxol) was achieved on pentafluorophenyl (PFP) HPLC columns. Methods using aqueous acetonitrile gradients on each of two commercial PFP columns ...

Determination of cephalomannine in rat plasma by gradient elution UPLC-MS/MS method.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 963 , 70-4, (2014)

A rapid, sensitive and selective ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of ce...

Microbial transformation of cephalomannine by Luteibacter sp.

J. Nat. Prod. 70(12) , 1846-9, (2007)

Luteibacter sp., a new bacterium isolated from the soil around a Taxus cuspidata Sieb. et Zucc plant, was studied for its capability to metabolize cephalomannine (1). After preparative fermentation, e...

 Synonyms

Paclitaxel Related CoMpound A
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecah ydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
benzenepropanoic acid, α-hydroxy-β-[[(2E)-2-methyl-1-oxo-2-buten-1-yl]amino]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
chephalomannine
(2α,5β,7β,10β,13α)-4,10-Diacetoxy-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methyl-2-butenoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
3'-N-(trans-2-methyl-2-butenoyl)-3'-N-debenzoylpaclitaxel
CEPHALOMANNINE:BENZENEPROPANOICACID,-HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OX...
caphalomannine
Paclitaxel Related Compound A (20 mg) (Ce-phalomannine)
(2α,5β,7β,10β,13α)-4,10-bis(acetyloxy)-1,7-dihydroxy-13-{[(2R,3S)-2-hydroxy-3-{[(2E)-2-methylbut-2-enoyl]amino}-3-phenylpropanoyl]oxy}-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
TAXOL B
CEPHALOMANNINE:BENZENEPROPANOICACID,-HYDROXY--[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1
CEPHALOMANNINE (TAXOL B)
CEPHALOMANNINE(P)
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Cephalomannine suppliers

Price: $242/10mM*1mLinDMSO

Reference only. check more Cephalomannine price

Related Compounds: More...
Isocephalomannine
173101-54-7
7-Epicephalomannine
150547-36-7
7-epi-10-Deacetyl CephaloMannine
78479-12-6
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
849349-65-1
N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine
127437-46-1
Chemsrc provides Cephalomannine(CAS#:71610-00-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cephalomannine are included as well.>> amp version: Cephalomannine

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved