DC Chemicals Limited
China
Product Name: CI-966 hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-[2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]METHOXY]ETHYL]-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

110283-66-4

110283-66-4 structure

110283-66-4 structure

Name: CI 966 hydrochloride
Chemical Name: 1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrochloride
CAS Number: 110283-66-4
Molecular Formula: C₂₃H₂₂ClF₆NO₃
Molecular Weight: 509.86900
Create Date: 2019-01-12 18:37:22
Modify Date: 2024-02-04 00:16:42
CI-966 is a potent, selective inhibitor of the GABA transporter GAT-1 with IC50 of 0.26 and 1.2 uM for human and rat GAT-1, respectively.

Name	1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrochloride
Synonyms	3-Pyridinecarboxylic acid Nicotinimidamide 3-PYRDINECARBOXIMIDAMIDE 3-carbamidinopyridine Nicotinamidin 3-Amidinopyridine pyridine-3-carboximidamide

Boiling Point	514.1ºC at 760mmHg
Molecular Formula	C₂₃H₂₂ClF₆NO₃
Molecular Weight	509.86900
Flash Point	264.7ºC
Exact Mass	509.11900
PSA	49.77000
LogP	6.28680
Vapour Pressure	2.16E-11mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US5908290

CHEMICAL NAME :: 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-1-(2-(bis(4-(trifluoromethyl)pheny l)methoxy) ethyl)-, hydrochloride

CAS REGISTRY NUMBER :: 110283-66-4

LAST UPDATED :: 199403

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C23-H21-F6-N-O3.Cl-H

MOLECULAR WEIGHT :: 509.91

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 894 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - coma Gastrointestinal - hypermotility, diarrhea

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 703 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea Kidney, Ureter, Bladder - other changes

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/kg/4W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Endocrine - hyperglycemia Related to Chronic Data - death

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 420 mg/kg/4W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia

REFERENCE :: DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 28,65,1993

Hazard Codes	Xi