52497-36-6

52497-36-6 structure

Name: Dihydrokainic acid
Chemical Name: dihydrokainic acid
CAS Number: 52497-36-6
Molecular Formula: C₁₀H₁₇NO₄
Molecular Weight: 215.25
Catalog: Signaling Pathways Membrane Transporter/Ion Channel EAAT2
Create Date: 2018-12-27 14:28:17
Modify Date: 2025-09-10 18:48:44
Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1].

Name	dihydrokainic acid
Synonyms	2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid MFCD03412037 (2S,3S,4R)-3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid Dihydrokainic acid

Description	Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2 Research Areas >> Neurological Disease
Target	GLT1[1]
References	[1]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32. [2]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H332
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
HS Code	2933990090

487-79-6

52497-36-6

Literature: Ueno et al. Yakugaku Zasshi, 1955 , vol. 75, p. 836 Chem.Abstr., 1956 , p. 4118

Precursor 1
487-79-6
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%