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487-79-6

487-79-6 structure

487-79-6 structure

Name: Kainic acid
Chemical Name: kainic acid
CAS Number: 487-79-6
Molecular Formula: C₁₀H₁₅NO₄
Molecular Weight: 213.230
Catalog: Research Areas Neurological Disease
Create Date: 2018-05-12 08:00:00
Modify Date: 2024-01-02 20:35:45
Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS.

Name	kainic acid
Synonyms	KAINATE helminal kainic acid Kainic digenin Dihydroergocristine mesylate (3S,4S)-3-(Carboxymethyl)-4-isopropenyl-L-proline digenicacid (−)-Kainic Acid L-Proline, 3-(carboxymethyl)-4-(1-methylethenyl)-, (3S,4S)-

Description	Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease
In Vivo	Kainic acid is a potent agonist at excitatory amino acid receptor subtypes in the CNS. HO-I levels are significantly enhanced one, three and seven days after i.c.v, injection of Kainic acid. One day after i.c.v, injection of Kainic acid, the HO-I protein level reaches a maximum and then decreases, but is still significantly enhanced versus the vehicle-injected group. After i.c.v. injection of Kainic acid, HO-I-immunoreactivity is strongly induced not only in the CA3 but also widely in the whole hippocampus[1].
Animal Admin	The rats are fasted over night with free access to water. For stereotaxic injection, rats are anaesthetized (sodium pentobarbital, 50 mg/kg, i.p.) and immobilized in a Kopf stereotaxic frame. The rats are microinjected with 1 μg Kainic acid in 2 μL of sterilized physiological saline into the right lateral ventricle, i.e., 0.2 mm caudal from the bregma, 1.2 mm right lateral and 3.8 mm ventral according to the rat brain atlas. For control, rats are injected with same amount (2 μL) of vehicle, sterilized physiological saline. Five rats in each group are used in this study[1].
References	[1]. Matsuoka Y, et al. Kainic acid induction of heme oxygenase in vivo and in vitro. Neuroscience. 1998 Aug;85(4):1223-33.

Density	1.2±0.1 g/cm3
Boiling Point	439.9±45.0 °C at 760 mmHg
Melting Point	253-254ºC
Molecular Formula	C₁₀H₁₅NO₄
Molecular Weight	213.230
Flash Point	219.8±28.7 °C
Exact Mass	213.100113
PSA	86.63000
LogP	0.50
Vapour Pressure	0.0±2.3 mmHg at 25°C
Index of Refraction	1.509
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX9665250

CHEMICAL NAME :: 3-Pyrrolidineacetic acid, 2-carboxy-4-isopropenyl-

CAS REGISTRY NUMBER :: 487-79-6

BEILSTEIN REFERENCE NO. :: 0086660

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H15-N-O4

MOLECULAR WEIGHT :: 213.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3 mg/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3 mg/kg

SEX/DURATION :: female 17-18 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - behavioral

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 3 mg/kg

SEX/DURATION :: female 19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

REFERENCE :: FOBGA8 Folia Biologica (Krakow). (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1953- Volume(issue)/page/year: 36,103,1988

Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	22-24/25-36
RTECS	UX9665250

Precursor 5
139407-08-2 329055-36-9 1293306-04-3 1259067-20-3
115890-38-5
DownStream 3
108365-31-7 487-79-6 52497-36-6