Dihydrokainic acid
Dihydrokainic acid structure
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Common Name | Dihydrokainic acid | ||
|---|---|---|---|---|
| CAS Number | 52497-36-6 | Molecular Weight | 215.25 | |
| Density | 1.187g/cm3 | Boiling Point | 416.6ºC at 760mmHg | |
| Molecular Formula | C10H17NO4 | Melting Point | 285 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Dihydrokainic acidDihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1]. |
| Name | dihydrokainic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1]. |
|---|---|
| Related Catalog | |
| Target |
GLT1[1] |
| References |
| Density | 1.187g/cm3 |
|---|---|
| Boiling Point | 416.6ºC at 760mmHg |
| Melting Point | 285 °C (dec.) |
| Molecular Formula | C10H17NO4 |
| Molecular Weight | 215.25 |
| Exact Mass | 215.11600 |
| PSA | 86.63000 |
| LogP | 0.73470 |
| Index of Refraction | 1.492 |
| Storage condition | 2-8°C |
|
~%
Dihydrokainic acid CAS#:52497-36-6 |
| Literature: Ueno et al. Yakugaku Zasshi, 1955 , vol. 75, p. 836 Chem.Abstr., 1956 , p. 4118 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.
J. Neurosci. 34(40) , 13472-85, (2014) The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit... |
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Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain.
Glia 62(9) , 1543-58, (2014) Signaling via the major excitatory amino acid glutamate has been implicated in the regulation of various aspects of the biology of oligodendrocytes, the myelinating cells of the central nervous system... |
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A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.
J. Physiol. 592(Pt 13) , 2813-27, (2014) Neuronal activity is controlled by a fine-tuned balance between intrinsic properties and extrinsic synaptic inputs. Moreover, neighbouring astrocytes are now recognized to influence a wide spectrum of... |
| 2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid |
| MFCD03412037 |
| (2S,3S,4R)-3-(carboxymethyl)-4-propan-2-ylpyrrolidine-2-carboxylic acid |
| Dihydrokainic acid |