142523-14-6
142523-14-6 structure
- Name: L-690,488
- Chemical Name: L-690,488,1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate
- CAS Number: 142523-14-6
- Molecular Formula: C32H52O16P2
- Molecular Weight: 754.69300
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphatase
- Create Date: 2017-09-24 04:23:25
- Modify Date: 2024-01-07 21:49:28
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L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. L-690488 has more effective cell penetration than L-690330[1][2].
| Name | L-690,488,1-[(4-Hydroxyphenoxy)ethylidene]bis[phosphinylidynebis(oxymethylene)]-2,2-dimethylpropanoate |
|---|---|
| Synonyms | l-690,488 |
| Description | L-690488 is a prodrug of L-690330 and is a selective inositol monophosphatase (IMPase) inhibitor. L-690488 has more effective cell penetration than L-690330[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Inositol monophosphatase (IMPase)[1][2] |
| In Vitro | The effects of L-690488 are studied in cholinergically (carbachol)-stimulated rat cortical slices and Chinese hamster ovary cells stably transfected with the human muscarinic m1 receptor (m1 CHO cells). The EC50 values of L-690488 are 3.7 μM and 1.0 μM in rat cortical slices and m1 CHO cells, respectively). The time course and maximum accumulation of [3H] CMP-PA in L-690488-treated m1 CHO cells is similar to lithium but L-690488 is again much more potent (EC50 values of 3.5 μM and 0.52 mM for L-690488 and lithium, respectively)[1]. L-690488 attenuates the carbachol-induced elevation of inositol 1,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate in m1 CHO cells. That these effects of L-690488 on the phosphatidylinositol (Pl) cycle are indeed due to inositol depletion[1]. |
| References |
| Molecular Formula | C32H52O16P2 |
|---|---|
| Molecular Weight | 754.69300 |
| Exact Mass | 754.27300 |
| PSA | 225.34000 |
| LogP | 7.08450 |