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  • DC Chemicals Limited
  • China
  • Product Name: Sirtinol
  • Price: $350.0/100mg $630.0/250mg $1250.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
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410536-97-9

410536-97-9 structure
410536-97-9 structure
  • Name: Sirtinol
  • Chemical Name: Sirtinol,2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
  • CAS Number: 410536-97-9
  • Molecular Formula: C26H22N2O2
  • Molecular Weight: 394.465
  • Catalog: Biochemical Inhibitor Epigenetics Sirtuin inhibitor
  • Create Date: 2018-12-04 17:18:09
  • Modify Date: 2024-01-02 20:46:30
  • Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
Name Sirtinol,2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Synonyms 2-{[(E)-(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-(1-phenylethyl)benzamide
2-{[(E)-(2-Hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide
sir two inhibitor naphthol
sirtinol
2-{(E)-[(2-Hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide
Benzamide, 2-[[(1E)-(2-hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)-
Description Sirtinol is a sirtuin inhibitor, with IC50s of 48 μM, 57.7 μM and 131 μM for ySir2, hSIRT2 and hSIRT2, respectively.
Related Catalog
Target

ySir2:48 μM (IC50)

hSIRT2:57.7 μM (IC50)

hSIRT1:131 μM (IC50)

In Vitro Sirtinol reduces the growth of MCF-7 cells in a concentration- and time-dependent manner. The IC50 values of sirtinol are 48.6 μM and 43.5 μM after 24 and 48 h of treatment, respectively. Sirtinol significantly decreases SIRT1 expression and increases the acetylated p53 level[1]. Sirtinol attenuates the proliferation and induces apoptosis of nonsmall cell lung cancer (NSCLC) H1299 cells and causes the significantly increased level of FoxO3a, a proapoptotic transcription factor targeted by Sirt1[2].
In Vivo Sirtinol has anti-inflammatory effects through direct inhibition of HNE activity and attenuates HNE-induced and LPS-mediated tissue or organ injury[3].
Cell Assay Sirtinol is dissolved in 100% DMSO at concentration of 10 mM and stored at −20°C until use. The cell proliferation of H1299 cells is determined by trypan blue dye exclusion assay. Human nonsmall cell lung cancer (NSCLC) cells are seeded in 12-well plates and treated with indicated concentrations of sirtinol (0, 10, 20, and 50 μM) for 24 h and 48 h, respectively. After incubation, the cells are stained by 0.2% trypan blue and counted by Countess[2].
Animal Admin Mice: 30 male mice (20–25 g, 7–8 weeks old) are used in this model. Briefly, mice are randomly divided into five groups; then mice are intraperitoneally injected with 50 μL DMSO (vehicle group) or sirtinol (2.5 or 5.0 mg/kg body weight). After 1 h, paw inflammation is induced . The thickness of the paw is measured before and after HNE or saline injection[3].
References

[1]. Wang J, et al. Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109.

[2]. Fong Y, et al. The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051.

[3]. Tsai YF, et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347.

[4]. Mai A, et al. Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.
Density 1.2±0.1 g/cm3
Boiling Point 659.2±50.0 °C at 760 mmHg
Melting Point 119-120℃
Molecular Formula C26H22N2O2
Molecular Weight 394.465
Flash Point 352.5±30.1 °C
Exact Mass 394.168121
PSA 61.69000
LogP 6.20
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.623
Storage condition −20°C
Water Solubility Soluble in water, DMSO and methanol
WGK Germany 3
HS Code 2925290090
85592-80-9 structure

85592-80-9

708-06-5 structure

708-06-5

~96%

410536-97-9 structure

410536-97-9

Literature: US2009/137681 A1, ; Page/Page column 30; 32-33 ; US 20090137681 A1
Precursor  2

DownStream  0

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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title: CAS No. 410536-97-9 | Chemsrc address: https://m.chemsrc.com/en/baike/754054.html

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