54-31-9
54-31-9 structure
- Name: Furosemide
- Chemical Name: furosemide
- CAS Number: 54-31-9
- Molecular Formula: C12H11ClN2O5S
- Molecular Weight: 330.744
- Catalog: API Urinary system medication Diuretic
- Create Date: 2018-02-08 08:00:00
- Modify Date: 2026-07-01 13:53:46
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Furosemide (Lasix) is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter of which used in the treatment of congestive heart failure and edema.Target: NKCC Furosemide (INN/BAN) or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi under the brand name Lasix, and also under the brand names Fusid and Frumex. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.Along with some other diuretics, furosemide is also included on the World Anti-Doping Agency's banned drug list due to its alleged use as a masking agent for other drugs.Furosemide, like other loop diuretics, acts by inhibiting NKCC2, the luminal Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance.Because of the large NaCl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors. Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of α6β2γ2 receptors at uM concentrations, but not α1β2γ2 receptors. During development, the α6β2γ2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to furosemide
| Name | furosemide |
|---|---|
| Synonyms |
FUROSEMIDE UNLABELED 1.0 MG/ML IN METHANOL
furesis Odemase 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid, 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid Furosemide,5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoicacid Frusemide frusid FUROSEMIDE,1.0MG/MLINMETHANOL dryptal 4-chloro-n-(2-furylmethyl)-5-sulfanoylanthranilicacid trofurit Nicorol FUROSEMIDE, BP STANDD(CRM STANDD) EINECS 200-203-6 Urex Furosemide (furosemide) FUROSEMIDE, STANDD ANTI-TM173(C-TERMINAL) antibody produced in rabbit macasirool 5-(aminosulfonyl)-4-chloro-2-((2-furanylmethyl)amino)-benzoicaci lasilix Oedemex Lazax Transmembrane protein endural Discoid katlex chlor-n-(2-furylmethyl)-5-sulfamylanthranilsaeure furose TMEM173 asemide Furosemide for peak identification 4-Chloro-2-[(2-furylmethyl)amino]-5-sulfamoylbenzoic acid aquasin 4-CHLORO-N-(2-FURYLMETHYL)-5-SULPHAMOYLANTHRANILICACID FUROSEMIDE, IMPURITY A2-CHLORO-4-(FURFURYLAMINO)-5-SULPHAMOYLBENZOIC ACID STANDD FUROSEMIDE, MM(CRM STANDD) FUROSEMIDE Furosemide solution FUROSEMIDE, IMP. B : 2,4-DICHLORO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDD) Benzoic acid, 5-(aminosulfonyl)-4-chloro-2-(2-furanylmethyl)amino 4-chloro-n-furfuryl-5-sulfamoyl-anthranilicaci 5-[AMINOSULFONYL]-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID 5-(Aminosulfonyl)-4-chloro-2-[(2-pyranylmethyl)-amino]benzonium acid Mirfat Furix Frumex furosedon FUROSEMIDE (FRUSEMIDE) Durafurid FUROSEMIDE, RELATED COMPOUND A 2-CHLORO-4-N-FURFURYLAMINO-5-SULFAMOYLBENZOIC ACID STANDD FUROSEMIDE, IMP. A :2-CHLORO-4-FURFURYLAMINO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDD) 4-chloro-2-(2-furylmethylamino)-5-sulfamoyl-benzoic acid franyl Frusetic Errolon FUROSEMIDE, IMP. C : 2-AMINO-4-CHLORO-5-SULPHAMOYLBENZOIC ACID MM(CRM STANDD) 5-(Aminosulfonyl)-4-chloro-2-[2-(furamyl-methyl)amino]-benzoicacid frusemin Furosemid 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]-benzoicaci Furomex "mita" aluzine FRUSEMIDE Impugan FUROSEMIDE, WHO(CRM STANDD) furanthril profemin 2-furfurylamino-4-chloro-5-sulfamoylbenzoic acid desdemin LABOTEST-BB LT00244801 4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID Fusid FUROSEMIDE, RELATED COMPOUND B 4-CHLORO-5-SULFAMOYLANTHRANILIC ACID STANDD furantril FUROSEMID Lasix Eutensin fulsix furanthryl rosemide diurolasa MFCD00010549 Fuluvamide 4-Chloro-N-Furfuryl-5-Sulfamoylanthranilic Acid N-(2-furylmethyl)-4-chloro-5-sulfamylanthranilic acid FUROSEMIDE METHANOL SOLUTION 5-(AMINOSULPHONYL)-4-CHLORO-2-[(2-FURANYLMETHYL)AMINO]BENZOIC ACID |
| Description | Furosemide (Lasix) is a loop diuretic inhibitor of Na+/2Cl-/K+ (NKCC) cotransporter of which used in the treatment of congestive heart failure and edema.Target: NKCC Furosemide (INN/BAN) or frusemide is a loop diuretic used in the treatment of congestive heart failure and edema. It is most commonly marketed by Sanofi under the brand name Lasix, and also under the brand names Fusid and Frumex. It has also been used to prevent Thoroughbred and Standardbred race horses from bleeding through the nose during races.Along with some other diuretics, furosemide is also included on the World Anti-Doping Agency's banned drug list due to its alleged use as a masking agent for other drugs.Furosemide, like other loop diuretics, acts by inhibiting NKCC2, the luminal Na-K-2Cl symporter in the thick ascending limb of the loop of Henle. The action on the distal tubules is independent of any inhibitory effect on carbonic anhydrase or aldosterone; it also abolishes the corticomedullary osmotic gradient and blocks negative, as well as positive, free water clearance.Because of the large NaCl absorptive capacity of the loop of Henle, diuresis is not limited by development of acidosis, as it is with the carbonic anhydrase inhibitors. Additionally, furosemide is a noncompetitive subtype-specific blocker of GABA-A receptors. Furosemide has been reported to reversibly antagonize GABA-evoked currents of α6β2γ2 receptors at uM concentrations, but not α1β2γ2 receptors. During development, the α6β2γ2 receptor increases in expression in cerebellar granule neurons, corresponding to increased sensitivity to furosemide |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 582.1±60.0 °C at 760 mmHg |
| Melting Point | 220 °C (dec.)(lit.) |
| Molecular Formula | C12H11ClN2O5S |
| Molecular Weight | 330.744 |
| Flash Point | 305.9±32.9 °C |
| Exact Mass | 330.007721 |
| PSA | 131.01000 |
| LogP | 3.10 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.658 |
| Stability | Stable, but light sensitive, air sensitive and hygroscopic. Incompatible with strong oxidizing agents. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H360 |
| Precautionary Statements | P201-P308 + P313 |
| Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic; |
| Risk Phrases | R61 |
| Safety Phrases | S7-S16-S36/37-S45-S53-S36/37/39-S22 |
| RIDADR | UN 1230 3/PG 2 |
| WGK Germany | 3 |
| RTECS | CB2625000 |
| HS Code | 2942000000 |
| Precursor 0 | |
|---|---|
| DownStream 5 | |
![4-chloro-2-[(2,5-dimethoxy-2,5-dihydro-furan-2-ylmethyl)-amino]-5-sulfamoyl-benzoic acid structure](https://image.chemsrc.com/caspic/316/1351169-05-5.png)
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |