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  • Product Name: McN-A-343
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  • Purity: 98.0%
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55-45-8

55-45-8 structure
55-45-8 structure
  • Name: McN-A 343
  • Chemical Name: 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride
  • CAS Number: 55-45-8
  • Molecular Formula: C14H18Cl2N2O2
  • Molecular Weight: 317.21100
  • Create Date: 2016-10-19 07:25:25
  • Modify Date: 2024-01-02 11:04:30
  • McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2].

Name 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride
Synonyms MCN A-343 chloride
McN-A-343
A 343
Description McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2].
Related Catalog
References

[1]. Koss MC, et al. Analysis of miosis produced by McN-A-343 in anesthetized cats. J Ocul Pharmacol Ther. 1995;11(3):389-399.

[2]. Magalhães DA, Batista JA, Sousa SG, et al. McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis. Life Sci. 2021;272:119194.

Molecular Formula C14H18Cl2N2O2
Molecular Weight 317.21100
Exact Mass 316.07500
PSA 38.33000
Storage condition -20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BR0318000
CHEMICAL NAME :
Ammonium, (4-hydroxy-2-butynyl)trimethyl-, chloride, m-chlorocarbanilate
CAS REGISTRY NUMBER :
55-45-8
LAST UPDATED :
199009
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H18-Cl-N2-O2.Cl
MOLECULAR WEIGHT :
317.24
WISWESSER LINE NOTATION :
GR CMVO2UU2K &G &12/15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
34375 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 13,307,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1174 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,281,1990
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases 24/25
RIDADR NONH for all modes of transport
RTECS BR0318000
Precursor  2

DownStream  0