Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: 4-(N-[3-CHLOROPHENYL]-CARBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE
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55-45-8

55-45-8 structure

Name: McN-A 343
Chemical Name: 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride
CAS Number: 55-45-8
Molecular Formula: C₁₄H₁₈Cl₂N₂O₂
Molecular Weight: 317.21100
Create Date: 2016-10-19 07:25:25
Modify Date: 2026-07-01 07:38:01
McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2].

Name	4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride
Synonyms	4-[(3-chlorophenyl)cbamoyloxy]but-2-ynyl-trimethylazanium chloride (4-hydroxy-2-butynyl)-1-trimethyl-ammonium-3-chloro-cbanilate chloride ammonium,(4-hydroxy-2-butynyl)trimethyl-,chloride,m-chlorocbanilate (4-Hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocbanilate chloride, 4-[N-(3-Chlorophenyl)cbamoyloxy]-2-butynyltrimethylammonium chloride 4-(N-[3-CHLOROPHENYL]-CBAMOYLOXY)-2-BUTYNYLTRIMETHYLAMMONIUM CHLORIDE m-chloro-cbanilicaciesterwith(4-hydroxy-2-butynyl)trimethylammonium McN A 343,McNA 4-(N-(3-CHLOROPHENYL)CBAMOYLOXY)-2-BUT YNYLTRIMET 4-(N-(3-chlorophenyl)cbamoyloxy)-2-*butynyltrim 4-[(3-chlorophenyl)cbamoyloxy]but-2-ynyl-trimethyl-ammonium chloride MCN A-343 chloride 4-[(3-chlorophenyl)cbamoyloxy]but-2-ynyl-trimethyl-azanium chloride 4-[[[(3-Chlorophenyl)amino]carbonyl]oxy]-N,N,N-trimethyl-2-butyn-1-aminiumchloride MCN A-343 A 343 McN-A-343 mcna-343chloride 4-((((3-chlorophenyl)amino)carbonyl)oxy)-n,n,n-trimethyl-butyl-1-aminiuc a343 McNeil-A343 (4-(m-chlorophenylcbamoyloxy)-2-butynyl)trimethylammoniumchloride

Description	McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Inflammation/Immunology
References	[1]. Koss MC, et al. Analysis of miosis produced by McN-A-343 in anesthetized cats. J Ocul Pharmacol Ther. 1995;11(3):389-399. [2]. Magalhães DA, Batista JA, Sousa SG, et al. McN-A-343, a muscarinic agonist, reduces inflammation and oxidative stress in an experimental model of ulcerative colitis. Life Sci. 2021;272:119194.

CHEMICAL NAME :: Ammonium, (4-hydroxy-2-butynyl)trimethyl-, chloride, m-chlorocarbanilate

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 13,307,1968

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 33,281,1990

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
RTECS	BR0318000

101-27-9

75-50-3

55-45-8

Literature: Hopkins,T.R. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 659 - 662

Precursor 2
101-27-9 75-50-3
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