McN-A 343
McN-A 343 structure
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Common Name | McN-A 343 | ||
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| CAS Number | 55-45-8 | Molecular Weight | 317.21100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H18Cl2N2O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of McN-A 343McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C14H18Cl2N2O2 |
|---|---|
| Molecular Weight | 317.21100 |
| Exact Mass | 316.07500 |
| PSA | 38.33000 |
| InChIKey | CXFZFEJJLNLOTA-UHFFFAOYSA-N |
| SMILES | C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1.[Cl-] |
| Storage condition | -20°C |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| RTECS | BR0318000 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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McN-A 343 CAS#:55-45-8 |
| Literature: Hopkins,T.R. et al. Journal of Organic Chemistry, 1962 , vol. 27, p. 659 - 662 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
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| DownStream 0 | |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Central muscarinic cholinergic activation alters interaction between splenic dendritic cell and CD4+CD25- T cells in experimental colitis.
PLoS ONE 9(10) , e109272, (2014) The cholinergic anti-inflammatory pathway (CAP) is based on vagus nerve (VN) activity that regulates macrophage and dendritic cell responses in the spleen through alpha-7 nicotinic acetylcholine recep... |
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Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.
J. Pharmacol. Sci. 125(2) , 157-68, (2014) The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) bind... |
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Investigating the interaction of McN-A-343 with the M2 muscarinic receptor using its nitrogen mustard derivative.
Biochem. Pharmacol. 79(7) , 1025-35, (2010) We investigated whether the aziridinium ion formed from a nitrogen mustard derivative (4-[(2-bromoethyl)methyl-amino]-2-butynyl N-(3-chlorophenyl)carbamate; BR384) structurally related to McN-A-343 (4... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: In vivo determination of peripheral M2 receptor mediated hypothermia, cholinergic sid...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL750964
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Name: In vivo determination of peripheral M2 receptor mediated tremor, cholinergic side eff...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL750967
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Name: In vivo determination of peripheral M2 receptor mediated salivation, cholinergic side...
Source: ChEMBL
Target: Muscarinic acetylcholine receptor M2
External Id: CHEMBL750966
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Name: Human M5 receptor (Acetylcholine receptors (muscarinic))
Source: IUPHAR-DB
Target: M5 receptor (Acetylcholine receptors (muscarinic)) [Homo sapiens]
External Id: 17_Human
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Name: Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste...
Source: Broad Institute
Target: N/A
External Id: 7124-01_Inhibitor_SinglePoint_HTS_Activity
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Name: Dicer-mediated maturation of pre-microRNA
Source: Center for Chemical Genomics, University of Michigan
Target: N/A
External Id: TargetID_659_CEMA
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| MCN A-343 chloride |
| McN-A-343 |
| A 343 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the upstream materials of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: Related upstream materials(CAS) of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride: 101-27-9;75-50-3. |
| Q: What is the InChIKey of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: InChIKey of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride is CXFZFEJJLNLOTA-UHFFFAOYSA-N. |
| Q: What is the molecular weight of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: Molecular weight of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride is 317.21100. |
| Q: What is the CAS number of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: CAS number of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride is 55-45-8. |
| Q: What are the uses of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: Main uses of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride: McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 reduces inflammation and oxidative stress in an experimental model of ulcerative colitis[1][2]. |
| Q: What is the safety information for 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: Safety information for 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride: 24/25. |
| Q: What is the polar surface area (PSA) of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: Polar surface area (PSA) of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride is 38.33000. |
| Q: What are the storage conditions for 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: Storage conditions for 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride: -20°C. |
| Q: What is the English name of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: The English name of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride is 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride. |
| Q: What is the SMILES notation of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride? |
| A: SMILES notation of 4-[(3-chlorophenyl)carbamoyloxy]but-2-ynyl-trimethylazanium,chloride is C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1.[Cl-]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |