Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Xanthurenic acid
Price:
Purity: 97.0%
Stocking Period: 10 Day
Contact: Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Xanthurenic acid
Price: ￥2688.0/5g ￥678.0/1g
Purity: 96.0%
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Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,8-Dihydroxyquinoline-2-carboxylic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

59-00-7

59-00-7 structure

59-00-7 structure

Name: Xanthurenic acid
Chemical Name: xanthurenic acid
CAS Number: 59-00-7
Molecular Formula: C₁₀H₇NO₄
Molecular Weight: 205.167
Catalog: Pharmaceutical intermediate Heterocyclic compound Quinoline compound
Create Date: 2018-09-17 09:31:08
Modify Date: 2024-01-02 22:52:53
Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.

Name	xanthurenic acid
Synonyms	4,8-Dihydroxy-2-quinolinecarboxylic acid EINECS 200-410-1 4,8-dihydroxy-Quinaldic acid 4,8-Dihydroxyquinoline-2-carboxylic acid 2-quinolinecarboxylic acid, 1,4-dihydro-8-hydroxy-4-oxo- 8-hydroxy-4-oxo-1H-quinoline-2-carboxylic acid Xanthurenate Xanthurenic acid MFCD00006754 2-Quinolinecarboxylic acid, 4,8-dihydroxy-

Description	Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Metabolic Disease Natural Products >> Acids and Aldehydes Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite mGluR2 mGluR3
In Vivo	Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. The inhibition of Xanthurenic acid (XA) on sensory can be found when applied iontophoretically and i.v., is similar to that of other Group II mGlu receptor agonists in reducing inhibition evoked in the VB from the thalamic reticular nucleus upon physiological sensory stimulation. Furthermore, it is postulated that Xanthurenic acid may be the first potential endogenous allosteric agonist for the mGlu receptors. As the Group II receptors and kynurenine metabolism pathway have both been heavily implicated in the pathophysiology of schizophrenia, Xanthurenic acid could play a pivotal role in antipsychotic research as this potential endocoid represents both a convergence within these two biological parameters and a novel class of Group II mGlu receptor ligand[1].
Animal Admin	Rats[1]Male Wistar rats (265-495 g, n=27) are used throughout the study. Throughout the experiments, electrocardiogram and electroencephalogram (EEG) are monitored. Iontophoretic drug applications are performed using the outer barrels, with one of the outer barrels filled with 1 M NaCl for current balancing on each occasion. The remaining outer barrels contain one of the following substances as required: NMDA (50 mM,pH8.0 in 150 mM NaCl), LY354740 (5 mM, pH8.0 in 75 mM NaCl), Xanthurenic Acid (5 mM, pH8.0 in 75 mM NaCl), LY341495 (5 mM, pH8.5 in 75mM NaCl), as Nat salts, ejected as anions, and LY487379 (1 mM, pH6.0, in 1% dimethyl sulfoxide, 75mM NaCl), ejected as cations. All compounds are prevented from diffusing out of the pipette by using a retaining current (15-25 nA) of opposite polarity to that of the ejection current[1].
References	[1]. Copeland CS, et al. Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. Neuropharmacology. 2013 Mar;66:133-42.

Density	1.6±0.1 g/cm3
Boiling Point	514.4±50.0 °C at 760 mmHg
Melting Point	297-298 °C (dec.)(lit.)
Molecular Formula	C₁₀H₇NO₄
Molecular Weight	205.167
Flash Point	264.9±30.1 °C
Exact Mass	205.037506
PSA	90.65000
LogP	2.64
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.779
Storage condition	Store at RT

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UZ9275000

CHEMICAL NAME :: Quinaldic acid, 4,8-dihydroxy-

CAS REGISTRY NUMBER :: 59-00-7

BEILSTEIN REFERENCE NO. :: 0185954

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H7-N-O4

MOLECULAR WEIGHT :: 205.18

WISWESSER LINE NOTATION :: T66 BNJ CVQ EQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Kidney, Ureter, Bladder - tumors

REFERENCE :: ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- Volume(issue)/page/year: 108,924,1963 *** REVIEWS *** TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UZ9275000