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1989-52-2

1989-52-2 structure
1989-52-2 structure
  • Name: Cholesterol myristate
  • Chemical Name: cholesteryl myristate
  • CAS Number: 1989-52-2
  • Molecular Formula: C41H72O2
  • Molecular Weight: 597.00900
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2018-04-24 08:00:00
  • Modify Date: 2024-01-02 23:31:07
  • Cholesterol myristate is a natural steroid present in traditional Chinese medicine.

Name cholesteryl myristate
Synonyms Cholesterol=tetradecanoate
CHOLESTERYL TETRADODEDECANOATE
EINECS 217-867-8
Cholesteryl myristate
Cholest-5-en-3-yl myristate
Cholesterol Myristate
Cholestryl myristate
MFCD00014256
Myristic Acid Cholesterol Ester
O-myristoyl-cholesterol
cholesteryl tetradecanoate
Cholestryl myristic acid
Myristinsaeure-cholesterylester
Description Cholesterol myristate is a natural steroid present in traditional Chinese medicine.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1].
Cell Assay MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1].
References

[1]. Chen DF, et al. Cholesterol myristate suppresses the apoptosis of mesenchymal stem cells via upregulation of inhibitor of differentiation. Steroids. 2010 Dec 12;75(13-14):1119-26.

[2]. Chen DF, et al. BMP-Id pathway targeted by cholesterol myristate suppresses the apoptosis of PC12 cells. Brain Res. 2011 Jan 7;1367:33-42.

Density 0.95 g/cm3
Boiling Point 630.7ºC at 760 mmHg
Melting Point 84 °C
Molecular Formula C41H72O2
Molecular Weight 597.00900
Flash Point 334.8ºC
Exact Mass 596.55300
PSA 26.30000
LogP 12.64070
Vapour Pressure 8.15E-16mmHg at 25°C
Index of Refraction 1.506
Storage condition −20°C
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36
WGK Germany 3
Precursor  4

DownStream  0