52238-35-4

52238-35-4 structure

Name: 9-Hydroxyellipticine hydrochloride
Chemical Name: 5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol,hydrochloride
CAS Number: 52238-35-4
Molecular Formula: C₁₇H₁₅ClN₂O
Molecular Weight: 298.76700
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2016-06-21 15:07:41
Modify Date: 2024-01-10 12:01:25
9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].

Name	5,11-dimethyl-6H-pyrido[4,3-b]carbazol-9-ol,hydrochloride
Synonyms	Ellipticine,hydrochloride ELLIPTICINE ANALOG 9-HE,HCl 9-Hydroxyellipticine HCl 9 OHE HCl

Description	9-Hydroxyellipticine hydrochloride is a inhibitor of Topo II and RyR. 9-Hydroxyellipticine hydrochloride exhibits antitumor, antioxidant and catecholamine-releasing activities. 9-Hydroxyellipticine hydrochloride exhibits IC50 values of 1.6 μM and 1.2μM in Hela S-3 and 293T cells, respectively[1][2][3].
Related Catalog	Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase II
In Vitro	9-Hydroxyellipticine (9HE) causes selective inhibition of p53 protein phospborylation in Lewis lung carcinoma and SW480 (human colon cancer cell line) in a concentration-dependent manner from 0.1 to 100 μM[4].
In Vivo	9-Hydroxyellipticine (5 or 10 mg/kg, ip) results in chromosome clumping and sister chromatid exchange in murine bone marrow cells[1]. Animal Model: Three- to five-month-old C57B1/6 male mice[1]. Dosage: 5 or 10 mg/kg. Administration: IP. Result: Resulted in chromosome clumping, chromatid aberrations, and micronuclei formation in murine bone marrow cells.
References	[1]. Renault G, et al. In vivo exposure to four ellipticine derivatives with topoisomerase inhibitory activity results in chromosome clumping and sister chromatid exchange in murine bone marrow cells. Toxicol Appl Pharmacol. 1987 Jun 30;89(2):281-6. [2]. Saeki K, et al. Cardioprotective effects of 9-hydroxyellipticine on ischemia and reperfusion in isolated rat heart. Jpn J Pharmacol. 2002 May;89(1):21-8. [3]. Naoya Sato, et al. Synthesis and in vitro Antitumor Activity of 9-Hydroxyellipticine Derivatives with Glucose Conjugation via Triazolylmethyl Succinate Linker. Heterocycle, Vol. 92, NO 4, 2016. [4]. Ohashi M, et al. Inhibition of p53 protein phosphorylation by 9-hydroxyellipticine: a possible anticancer mechanism. Jpn J Cancer Res. 1995 Sep;86(9):819-27.

Density	1.349g/cm3
Boiling Point	557.7ºC at 760mmHg
Molecular Formula	C₁₇H₁₅ClN₂O
Molecular Weight	298.76700
Flash Point	291.1ºC
Exact Mass	298.08700
PSA	48.91000
LogP	4.99370

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