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Product Name: Sclareol
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Sclareol
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DC Chemicals Limited
China
Product Name: Sclareol
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Sclareol 515-03-7
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Purity: 99.0%
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515-03-7

515-03-7 structure

Name: Sclareol
Chemical Name: sclareol
CAS Number: 515-03-7
Molecular Formula: C₂₀H₃₆O₂
Molecular Weight: 308.499
Catalog: Flavors and spices Synthetic spice Alcoholic spice Terpene alcohol
Create Date: 2018-04-17 08:00:00
Modify Date: 2024-01-02 18:46:16
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis[1].

Name	sclareol
Synonyms	(1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-methyl-4-penten-1-yl]-2,5,5,8a-tetramethyldecahydro-2-naphthalenol (1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol SCLAREOL(RG) EINECS 208-194-0 1-Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, (αR,1R,2R,4aS,8aS)- Labd-14-ene-8,13-diol, (13R)- SCIADONIC ACID (1R,2R,8aS)-Decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol labd-14-ene-8,13(R)-diol MFCD00869558 SCLAREOL,NATURAL SCAREOL Sclareol (-)-sclareol SCLAREOL(P) (1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-méthyl-4-pentèn-1-yl]-2,5,5,8a-tétraméthyldécahydro-2-naphtalénol

Description	Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Sclareol is cytotoxic to 13 of 14 human leukemia cell lines tested, with IC50 values ranging from 6.0–24.2 μg/mL, but is not cytotoxic to peripheral blood mononuclear leukocytes within the same dose range[1].
References	[1]. Robert Tisserand, et al. Sclareol.Constituent profiles

Density	1.0±0.1 g/cm3
Boiling Point	398.3±15.0 °C at 760 mmHg
Melting Point	95-100 °C(lit.)
Molecular Formula	C₂₀H₃₆O₂
Molecular Weight	308.499
Flash Point	169.1±15.0 °C
Exact Mass	308.271515
PSA	40.46000
LogP	5.54
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.490
Storage condition	2-8C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK0301900

CHEMICAL NAME :: 1-Naphthalenepropanol, decahydro-alpha-ethenyl-2-hydroxy-alpha,2,5,5,8a-pent amethyl-, (1R-(1-alpha(R*),2-beta,4a-beta,8a-alpha))-

CAS REGISTRY NUMBER :: 515-03-7

BEILSTEIN REFERENCE NO. :: 2054148

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H36-O2

MOLECULAR WEIGHT :: 308.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,115S,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,115S,1992

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	QK0301900
HS Code	2906199090

54274-72-5

~0%

515-03-7

22628-62-2

Literature: Rogachev, Victor; Loehl, Thorsten; Markert, Thomas; Metz, Peter Arkivoc, 2012 , vol. 2012, # 3 p. 172 - 180

1158-77-6

515-03-7

1232-00-4

Literature: Leite, Mary Ann F.; Sarragiotto, Maria Helena; Imamura, Paulo M.; Marsaioli, Anita J. Journal of Organic Chemistry, 1986 , vol. 51, # 26 p. 5409 - 5410

596-85-0

515-03-7

1232-00-4

Literature: Scheidegger,U. et al. Helvetica Chimica Acta, 1962 , vol. 45, p. 400 - 435

Precursor 3
54274-72-5 1158-77-6 596-85-0
DownStream 9
3243-36-5 511-15-9 6790-58-5 105014-29-7
564-20-5 31207-65-5 67119-91-9 596-84-9
1227-93-6

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

515-03-7	1232-00-4
83324-51-0	467251-09-8
132796-57-7	14162-41-5
5153-92-4	38419-75-9
55881-96-4	70892-62-5