596-85-0

596-85-0 structure

Name: Manool
Chemical Name: manool
CAS Number: 596-85-0
Molecular Formula: C₂₀H₃₄O
Molecular Weight: 290.48300
Catalog: Natural product Lignans
Create Date: 2018-09-17 13:39:12
Modify Date: 2024-01-03 10:57:15
Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].

Name	manool
Synonyms	8,14-labdadien-13-ol MFCD01310996 MANOOL

Description	Manool is a diterpene from Salvia officinalis. Manool induces selective cytotoxicity in cancer cells. Manool arrests the cancer cells at the G(2)/M phase of the cell cycle[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Manool exhibits higher cytotoxic activity against HeLa (IC50=6.7 µg/mL) and U343 (IC50=6.7 µg/mL) cells[1]. Manool exhibits a protective effect against chromosome damage induced by MMS in HepG2 cells[3].
References	[1]. de Oliveira PF, et al. Manool, a Salvia officinalis diterpene, induces selective cytotoxicity in cancer cells. Cytotechnology. 2016;68(5):2139-2143. [2]. Pratsinis H, et al. Antiproliferative activity of Greek propolis. J Med Food. 2010;13(2):286-290. [3]. Nicolella HD, et al. Differential effect of manool--a diterpene from Salvia officinalis, on genotoxicity induced by methyl methanesulfonate in V79 and HepG2 cells. Food Chem Toxicol. 2014;72:8-12.