Sclareol

Modify Date: 2024-01-02 18:46:16

Sclareol Structure
Sclareol structure
 Common Name Sclareol
CAS Number 515-03-7 Molecular Weight 308.499
Density 1.0±0.1 g/cm3 Boiling Point 398.3±15.0 °C at 760 mmHg
Molecular Formula C20H36O2 Melting Point 95-100 °C(lit.)
MSDS Chinese USA Flash Point 169.1±15.0 °C

 Use of Sclareol


Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis[1].

 Names

Name sclareol
Synonym More Synonyms

 Sclareol Biological Activity

Description Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis[1].
Related Catalog
In Vitro Sclareol is cytotoxic to 13 of 14 human leukemia cell lines tested, with IC50 values ranging from 6.0–24.2 μg/mL, but is not cytotoxic to peripheral blood mononuclear leukocytes within the same dose range[1].
References

[1]. Robert Tisserand, et al. Sclareol.Constituent profiles

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 398.3±15.0 °C at 760 mmHg
Melting Point 95-100 °C(lit.)
Molecular Formula C20H36O2
Molecular Weight 308.499
Flash Point 169.1±15.0 °C
Exact Mass 308.271515
PSA 40.46000
LogP 5.54
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.490
Storage condition 2-8C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QK0301900
CHEMICAL NAME :
1-Naphthalenepropanol, decahydro-alpha-ethenyl-2-hydroxy-alpha,2,5,5,8a-pent amethyl-, (1R-(1-alpha(R*),2-beta,4a-beta,8a-alpha))-
CAS REGISTRY NUMBER :
515-03-7
BEILSTEIN REFERENCE NO. :
2054148
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C20-H36-O2
MOLECULAR WEIGHT :
308.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,115S,1992
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,115S,1992

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS QK0301900
HS Code 2906199090

 Customs

HS Code 2906199090
Summary 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles27

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Comprehensive two-dimensional gas chromatography (GC×GC) coupled with Mass Spectrometry (MS) is one of today's most powerful analytical platforms for detailed analysis of medium-to-high complexity sam...

Labdane diterpenoids from Salvia reuterana.

Phytochemistry 108 , 264-9, (2014)

Three labdane diterpenoids, 14α-hydroxy-15-chlorosclareol (1), 14α-hydroxy-15-acetoxysclareol (2), and 6β-hydroxy-14α-epoxysclareol (3), together with the known diterpenoids sclareol (4), 6β-hydroxysc...

Isolation, chemical, and biotransformation routes of labdane-type diterpenes.

Chem. Rev. 111(8) , 4418-52, (2011)

 Synonyms

(1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-methyl-4-penten-1-yl]-2,5,5,8a-tetramethyldecahydro-2-naphthalenol
(1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-methylpent-4-en-1-yl]-2,5,5,8a-tetramethyldecahydronaphthalen-2-ol
SCLAREOL(RG)
EINECS 208-194-0
1-Naphthalenepropanol, α-ethenyldecahydro-2-hydroxy-α,2,5,5,8a-pentamethyl-, (αR,1R,2R,4aS,8aS)-
Labd-14-ene-8,13-diol, (13R)-
SCIADONIC ACID
(1R,2R,8aS)-Decahydro-1-(3-hydroxy-3-methyl-4-pentenyl)-2,5,5,8a-tetramethyl-2-naphthol
labd-14-ene-8,13(R)-diol
MFCD00869558
SCLAREOL,NATURAL
SCAREOL
Sclareol
(-)-sclareol
SCLAREOL(P)
(1R,2R,4aS,8aS)-1-[(3R)-3-Hydroxy-3-méthyl-4-pentèn-1-yl]-2,5,5,8a-tétraméthyldécahydro-2-naphtalénol
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Chemsrc provides Sclareol(CAS#:515-03-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Sclareol are included as well.>> amp version: Sclareol

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