40951-69-7

40951-69-7 structure

Name: Taxiresinol
Chemical Name: 4-[4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]benzene-1,2-diol
CAS Number: 40951-69-7
Molecular Formula: C₁₉H₂₂O₆
Molecular Weight: 346.37
Catalog: Natural product Lignans
Create Date: 2018-10-04 09:15:26
Modify Date: 2024-01-20 13:24:52
Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1].

Name	4-[4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)oxolan-2-yl]benzene-1,2-diol
Synonyms	1,2-Benzenediol, 4-[(2S,3R,4R)-tetrahydro-4-[(4-hydroxy-3-methoxyphenyl)methyl]-3-(hydroxymethyl)-2-furanyl]- 4-[(2S,3R,4R)-4-(4-Hydroxy-3-methoxybenzyl)-3-(hydroxymethyl)tetrahydro-2-furanyl]-1,2-benzenediol

Description	Taxiresinol is an orally active and potent lignan, that can be isolated from the heartwood of Taxus baccata. Taxiresinol shows significant antinociceptive activity[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vivo	Taxiresinol (100 mg/kg，口服，一次) 对对苯醌(p-benzoquinone)诱导的小鼠腹部收缩表现出显著的镇痛作用[1]。 Animal Model: Male Swiss albino mice (20-25 g)[1] Dosage: 100 mg/kg Administration: Oral administration, sixty minutes after the oral administration of test sample, the mice were intraperitoneally injected with 0.1 ml/10 g body weight of 2.5% (v/v) p-benzoquinone solution in distilled H2O. Result: Showed significant antinociceptive activity against p-benzoquinone-induced abdominal contractions (writhing movements) in mice, with a inhibitory ratio of 37.8%.
References	[1]. Küpeli E, et al. Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L. J Ethnopharmacol. 2003 Dec;89(2-3):265-70.

Hazard Codes	Xi