206052-01-9
206052-01-9 structure
- Name: PPOH
- Chemical Name: 6-(2-Propargyloxyphenyl)hexanoic acid
- CAS Number: 206052-01-9
- Molecular Formula: C15H18O3
- Molecular Weight: 246.302
- Catalog: Signaling Pathways Immunology/Inflammation COX
- Create Date: 2016-10-24 12:27:46
- Modify Date: 2024-01-06 18:06:40
-
PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1].
| Name | 6-(2-Propargyloxyphenyl)hexanoic acid |
|---|---|
| Synonyms |
Benzenehexanoic acid, α-(2-propyn-1-yloxy)-
6-Phenyl-2-(2-propyn-1-yloxy)hexanoic acid 6-(2-propargyloxyphenyl)hexanoic acid Benzenehexanoic acid, 2-(2-propyn-1-yloxy)- 6-[2-(2-Propyn-1-yloxy)phenyl]hexanoic acid 6-(2-prop-2-ynoxyphenyl)hexanoic acid |
| Description | PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1]. |
|---|---|
| Related Catalog | |
| In Vitro | PPOH (5 μM) can inhibit CYP2C9 activity by 63 and 90%, respectively, in the absence and presence of the 30-min NADPH preincubation and 63% when the 30-min preincubation omitted NADPH[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 411.0±40.0 °C at 760 mmHg |
| Molecular Formula | C15H18O3 |
| Molecular Weight | 246.302 |
| Flash Point | 151.1±20.8 °C |
| Exact Mass | 246.125595 |
| PSA | 46.53000 |
| LogP | 3.05 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.534 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2918990090 |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |