PPOH
Modify Date: 2024-01-06 18:06:40
PPOH structure
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Common Name | PPOH | ||
|---|---|---|---|---|
| CAS Number | 206052-01-9 | Molecular Weight | 246.302 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 411.0±40.0 °C at 760 mmHg | |
| Molecular Formula | C15H18O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 151.1±20.8 °C | |
Use of PPOHPPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1]. |
| Name | 6-(2-Propargyloxyphenyl)hexanoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | PPOH, a fatty acid derivative, is a selective cyclooxygenase (COX) inhibitor that inhibits arachidonic acid cyclooxygenase activity in renal cortical microsomes. In addition, PPOH acts on CYP4A2 and CYP4A3 with the IC50 values of 22 μM and 6.5 μM, respectively[1]. |
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| Related Catalog | |
| In Vitro | PPOH (5 μM) can inhibit CYP2C9 activity by 63 and 90%, respectively, in the absence and presence of the 30-min NADPH preincubation and 63% when the 30-min preincubation omitted NADPH[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 411.0±40.0 °C at 760 mmHg |
| Molecular Formula | C15H18O3 |
| Molecular Weight | 246.302 |
| Flash Point | 151.1±20.8 °C |
| Exact Mass | 246.125595 |
| PSA | 46.53000 |
| LogP | 3.05 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.534 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2918990090 |
| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.
Int. J. Obes. 39 , 755-61, (2015) Adipocyte fatty acid-binding protein (FABP4) is a member of a highly conserved family of cytosolic proteins that bind with high affinity to hydrophobic ligands, such as saturated and unsaturated long-... |
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Ophiopogonin D maintains Ca2+ homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/EETs and suppressing ER stress.
Acta Pharmacol. Sin. 37 , 368-81, (2016) CYP2J3 in myocardium metabolizes arachidonic acid to 4 regioisomeric epoxyeicosatrienoic acids (EETs), which have diverse biological activities in rat heart. In this study we examined whether CYP2J3 w... |
| Benzenehexanoic acid, α-(2-propyn-1-yloxy)- |
| 6-Phenyl-2-(2-propyn-1-yloxy)hexanoic acid |
| 6-(2-propargyloxyphenyl)hexanoic acid |
| Benzenehexanoic acid, 2-(2-propyn-1-yloxy)- |
| 6-[2-(2-Propyn-1-yloxy)phenyl]hexanoic acid |
| 6-(2-prop-2-ynoxyphenyl)hexanoic acid |