10391-08-9

10391-08-9 structure
10391-08-9 structure
  • Name: macrocalin A
  • Chemical Name: (3R,3aR,6aS,8aS,11R,13aS,13bS)-3-hydroxy-4,4-dimethyl-10-methylenedecahydro-1H,8H-8a,11-methanocyclohepta[c]furo[3,4-e]chromene-8,9(10H)-dione
  • CAS Number: 10391-08-9
  • Molecular Formula: C20H26O5
  • Molecular Weight: 346.417
  • Catalog: Natural product Moss
  • Create Date: 2016-10-27 08:19:52
  • Modify Date: 2024-01-11 17:21:49
  • (-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1].

Name (3R,3aR,6aS,8aS,11R,13aS,13bS)-3-hydroxy-4,4-dimethyl-10-methylenedecahydro-1H,8H-8a,11-methanocyclohepta[c]furo[3,4-e]chromene-8,9(10H)-dione
Synonyms (1S,4S,8R,9R,12S,13S,16R)-9-Hydroxy-7,7-dimethyl-17-methylene-3,10-dioxapentacyclo[14.2.1.0.0.0]nonadecane-2,18-dione
5H-5a,8-Methano-11H-cyclohepta[c]furo[3,4-e][1]benzopyran-5,6(7H)-dione, decahydro-13-hydroxy-1,1-dimethyl-7-methylene-, (3aS,5aS,8R,10aS,10bS,13R,13aR)-
Description (-)-Isodocarpin (Isodocarpin), a diterpenoid, is a potent melanogenesis inhibitor with an IC50 of 0.19 μM in B16 4A5 cells. (-)-Isodocarpin inhibits the expression of tyrosinase, tyrosine-related protein (TRP)-1, and TRP-2 mRNA[1].
Related Catalog
References

[1]. Yoshiaki Manse, et al. Melanogenesis Inhibitory Activity of Diterpenoid and Triterpenoid Constituents from the Aerial Part of Isodon trichocarpus. Natural Product Communications. August 1, 2017.

Density 1.3±0.1 g/cm3
Boiling Point 568.7±50.0 °C at 760 mmHg
Melting Point 270-273℃
Molecular Formula C20H26O5
Molecular Weight 346.417
Flash Point 205.0±23.6 °C
Exact Mass 346.178009
PSA 72.83000
LogP 0.94
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.584
Hazard Codes Xi