500565-15-1

500565-15-1 structure

Name: HM03
Chemical Name: 4-[(6-chloro-2-methoxyacridin-10-ium-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol,chloride
CAS Number: 500565-15-1
Molecular Formula: C₂₆H₂₇ClN₄O₂
Molecular Weight: 499.43200
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2016-06-18 19:30:54
Modify Date: 2024-01-14 11:39:36
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].

Name	4-[(6-chloro-2-methoxyacridin-10-ium-9-yl)amino]-2-[(4-methylpiperazin-1-yl)methyl]phenol,chloride

Description	HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSPA5
In Vitro	HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1]. HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1]. HM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1]. Cell Viability Assay[1] Cell Line: HCT116 cells Concentration: 0.1, 1, 10, 25, 50 μM Incubation Time: 72 hours Result: Exhibited prominent inhibition effect (18% survival at 25 µM).
References	[1]. Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044‐3050.