4936-47-4

• 常用中文名：硝呋太尔
• 常用英文名：Nifuratel
• CAS号：4936-47-4
• 分子式：C₁₀H₁₁N₃O₅S
• 分子量：285.276
• 相关类别： 原料药 人工合成抗感染类药 硝基呋喃类药
• 发布时间：2018-05-06 08:00:00
• 更新时间：2026-07-03 18:05:32
• Nifuratel(NF 113, SAP 113)是广谱抗生素，具有抗细菌、真菌和毛滴虫的活性。

名称

• 中文名: 尼莫唑
• 英文名: Nifuratel
• 中文别名: 硝基呋喃杂质; 硝夫太尔; 硝呋太尔,硝夫呔尔; 5-[(甲硫基)甲基]-3-[[(5-硝基-2-呋喃基)亚甲基]氨基]-2-恶唑烷酮; 乙腈中硝呋太尔; 硝呋太尔|Nifuratel; 硝呋太尔/尼莫唑; 硝呋太尔原料药; 呋喃疏唑酮; 硝呋拉太; 硝呋拉太 标准品; 硝呋太尔原料; 硝呋太尔4-4; 硝呋太尔/尼莫唑/呋喃疏唑酮/硝呋拉太; 硝呋太尔杂质12; 硝呋太尔,10 MM DMSO 溶液; 硝夫呔尔
• 英文别名: Nifurtyl; Polmiror; 5-[(METHYLTHIO)METHYL]-3-[[(5-NITRO-2-FURANYL)METHYLENE]AMINO-]-2-OXAZO-LIDINONE; 2-Oxazolidinone,5-[(Methylthio)Methyl]-3-[[(5-nitro-2-furanyl)Methylene]amino]; Magmilor; Nifuratel, 10 mM in DMSO; 5-[(Methylsulfanyl)Methyl]-4-[(E)-[(5-nitrofuran-2-yl)Methylidene]amino]-1,3-oxazolidin-2-one; 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino)-2-oxazolidinon; 5-(MethylMercaptoMethyl)-3-(5-nitro-2-furfurylidenaMino)-2-oxazolidinone; 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino)-2-oxazolidinone; 5-(Methylsulfanylmethyl)-3-[(E)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one; UNII:U60U6P08SP; EINECS 225-576-2; 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone, Methylmercadone, Inimur, Macmiror, Magmilor, Omnes, Polmiror, Tydantil; MACMIROR; 5-methylthiomethyl-3-(5-nitrofurfurylideneamino)-2-oxazolidone; Tydantil; omnes; sap113; 5-((Methylthio)methyl)-3-(((5-nitrofuran-2-yl)methylene)amino)oxazolidin-2-one; 5-[(Methylthio)methyl]-3-[(5-nitrofurfurylidene)amino]-2-oxazolidinone; Nifuratel powder; Nifter; 5-[(Methylsulfanyl)methyl]-3-{(E)-[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one; Methylmercadone; NIFURATEL; magmilor; Omnes; MFCD00057257; Nifuratel in Acetonitrile; Inimur; polmiror; NIFURATEL (MACMIROR); nf113; Nitrofurateyr, Nitrofurateyr; Nifurtal; 5-(methylthiomethyl)-3-((5-nitrofuran-2-yl)methyleneamino)oxazolidin-2-one; Nifuratel //BP; Macmiror; l’n-(5-nitro-2-furfurilidene)-3-amino-5-metilmercaptometil-2-ossazolidinone; Nifurate; Nimozole; 5-(Methylmercaptomethyl)-3-(5-nitro-2-furfurylideneamino)-2-oxazolidinone; 5-[(Methylthio)methyl]-3-[[(5-nitro-2-furanyl)methylene]amino]-2-oxazolidinone; 5-[(methylthio)methyl]-3-[(Z)-(5-nitro-2-furanyl)methylideneamino]-2-oxazolidinone; 3-[(5-Nitro-2-furfurylidene)amino]-5-[(Methylthio)Methyl]-2-oxazolidinone; methylmercadone; 5-((Methylthio)methyl)-3-((5-nitrofurfurylidene)amino)-2-oxazolidinone; 5-[(Methylsulfanyl)methyl]-3-{[(E)-(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one

物化性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 423.6±53.0 °C at 760 mmHg
• 熔点: 176-178°C
• 分子式: C₁₀H₁₁N₃O₅S
• 分子量: 285.276
• 闪点: 210.0±30.9 °C
• 精确质量: 285.041931
• PSA: 126.16000
• LogP: 0.27
• 外观性状: 新鲜的黄色结晶或黄色粉末
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.666
• 储存条件: -20°C Freezer
• 分子结构:

  1、 摩尔折射率：68.11

  2、 摩尔体积（cm³/mol）：186.7

  3、 等张比容（90.2K）：520.6

  4、 表面张力（dyne/cm）：60.4

  5、 极化率（10-24cm3）：27.00

• 更多:

  1. 熔点（ºC）：79~80

生物活性

• 描述: Nifuratel(NF 113, SAP 113)是广谱抗生素,具有抗细菌、真菌和毛滴虫的活性。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  信号通路 >> 抗感染 >> 寄生物
  天然产物 >> 生物碱
  研究领域 >> 感染
• 参考文献:

  [1]. Polatti F. Bacterial vaginosis, Atopobium vaginae and nifuratel. Curr Clin Pharmacol. 2012 Feb 1;7(1):36-40.

  [2]. Nijevitch AA, et al. Helicobacter pylori eradication in childhood after failure of initial treatment: advantage of quadruple therapy withnifuratel to furazolidone. Aliment Pharmacol Ther. 2005 Nov 1;22(9):881-7.

  [3]. Nijevitch AA, et al. Nifuratel-containing initial anti-Helicobacter pylori triple therapy in children. Helicobacter. 2007 Apr;12(2):132-5.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : RQ3590000 CHEMICAL NAME : 2-Oxazolidinone, 5-((methylthio)methyl)-3-((5-nitrofurfurylidine)amino )- CAS REGISTRY NUMBER : 4936-47-4 LAST UPDATED : 199612 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C10-H11-N3-O5-S MOLECULAR WEIGHT : 285.30 WISWESSER LINE NOTATION : T5OJ BNW E1UN- AT5NVOTJ E1S1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 50 ng/plate REFERENCE : MIGIA6 Minerva Ginecologia. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1949- Volume(issue)/page/year: 31,263,1979

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38:Irritating to eyes, respiratory system and skin .
• 安全声明 (欧洲): S26-S36-S37/39
• WGK德国: 3