240129-43-5

240129-43-5 structure

Name: 7,27-dihydroxycholesterol
Chemical Name: 7β,27-dihydroxycholesterol
CAS Number: 240129-43-5
Molecular Formula: C₂₇H₄₆O₃
Molecular Weight: 418.65200
Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
Create Date: 2016-04-14 23:17:03
Modify Date: 2024-01-13 12:35:01
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].

Name	7β,27-dihydroxycholesterol
Synonyms	5-cholesten-3β,7β,27-triol

Description	7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
Target	RORγt:120 nM (Ki)
In Vitro	7ß,27-Dihydroxycholesterol (0.3 μM 或 6 μM; 2 h) 在体外分别诱导人类和小鼠 Th17 细胞产生 IL-17[1]。
In Vivo	7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17[1]。
References	[1]. Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8.