7,27-dihydroxycholesterol
Modify Date: 2024-01-13 12:35:01
7,27-dihydroxycholesterol structure
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Common Name | 7,27-dihydroxycholesterol | ||
|---|---|---|---|---|
| CAS Number | 240129-43-5 | Molecular Weight | 418.65200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H46O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 7,27-dihydroxycholesterol7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1]. |
| Name | 7β,27-dihydroxycholesterol |
|---|---|
| Synonym | More Synonyms |
| Description | 7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1]. |
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| Related Catalog | |
| Target |
RORγt:120 nM (Ki) |
| In Vitro | 7ß,27-Dihydroxycholesterol (0.3 μM 或 6 μM; 2 h) 在体外分别诱导人类和小鼠 Th17 细胞产生 IL-17[1]。 |
| In Vivo | 7ß,27-Dihydroxycholesterol (60 mg/kg;皮下注射; 每天 2 次，共 3 天) 在体内诱导小鼠产生 IL-17[1]。 |
| References |
| Molecular Formula | C27H46O3 |
|---|---|
| Molecular Weight | 418.65200 |
| Exact Mass | 418.34500 |
| PSA | 60.69000 |
| LogP | 5.33190 |
| Storage condition | -20°C |
| 5-cholesten-3β,7β,27-triol |