Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pempidine
Price: ￥318.0/1g
Purity: 97.0%
Stocking Period: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

79-55-0

79-55-0 structure

Name: Pempidine
Chemical Name: 1,2,2,6,6-pentamethylpiperidine
CAS Number: 79-55-0
Molecular Formula: C₁₀H₂₁N
Molecular Weight: 155.28000
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-03-30 08:00:00
Modify Date: 2025-08-25 11:47:38
Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension.

Name	1,2,2,6,6-pentamethylpiperidine
Synonyms	PIPERIDINE,1,2,2,6,6-PENTAMETHYL Pyrilene MFCD00006493 N-methyl-2,2,6,6-tetramethylpiperidine Perolysen EINECS 201-211-2 M+B 4486 Pempidine N,2,2,6,6-pentamethyl piperidine

Description	Pempidine is a ganglion-blocking drug, introduced as an oral treatment for hypertension.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Martin TJ, et al. Pharmacological evaluation of the antagonism of nicotine's central effects by mecamylamine and pempidine. J Pharmacol Exp Ther. 1990 Jul;254(1):45-51. [2]. L. BRETHERICK, Congeners of Pempidine with High Ganglion-blocking Activity. Nature, 1959, 184: 1707-1709 )

Density	0.858 g/mL at 25 °C(lit.)
Boiling Point	187-188 °C(lit.)
Melting Point	137-141ºC
Molecular Formula	C₁₀H₂₁N
Molecular Weight	155.28000
Flash Point	122 °F
Exact Mass	155.16700
PSA	3.24000
LogP	2.59720
Index of Refraction	n20/D 1.460(lit.)
Storage condition	Flammables area

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN2190000

CHEMICAL NAME :: Piperidine, 1,2,2,6,6-pentamethyl-

CAS REGISTRY NUMBER :: 79-55-0

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C10-H21-N

MOLECULAR WEIGHT :: 155.32

WISWESSER LINE NOTATION :: T6NTJ A1 B1 B1 F1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 184,1707,1959

Symbol	GHS02, GHS06
Signal Word	Danger
Hazard Statements	H226-H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R10
Safety Phrases	S26-S36/37
RIDADR	UN 1992 3/PG 3
WGK Germany	3
RTECS	TN2190000
Packaging Group	III
Hazard Class	3
HS Code	2933399090

771436-36-3

~75%

79-55-0

Literature: Caliskan, Hafize; Zaim, Oemer Synthetic Communications, 2010 , vol. 40, # 20 p. 3078 - 3083

54262-97-4

~80%

79-55-0

Literature: Rae, Ian D.; Woolcock, Mark L. Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 447 - 450

768-66-1

50-00-0

~31%

79-55-0

Literature: Kostyanovskii, R. G.; Shakhgel'diev, M. A.; Nabiev, O. G. Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 12 p. 2593 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 12 p. 2826 - 2827

768-66-1

79-55-0

Literature: US4208525 A1, ;

768-66-1

74-88-4

79-55-0

Literature: Journal of the American Chemical Society, , vol. 79, p. 5279,5286

80-48-8

79-55-0

Literature: Journal of the American Chemical Society, , vol. 79, p. 5439

1402724-32-6

79-55-0

Literature: Journal of the American Chemical Society, , vol. 134, # 42 p. 17384 - 17387

768-66-1

1193-82-4

79-55-0

Literature: Bulletin of the Chemical Society of Japan, , vol. 68, # 5 p. 1401 - 1408

Precursor 7
771436-36-3 54262-97-4 768-66-1 50-00-0
74-88-4 80-48-8 1193-82-4
DownStream 9
617-94-7 220418-56-4 768-66-1 5132-07-0
54262-97-4 13304-52-4 77387-57-6 80220-93-5
100-51-6

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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