Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Qc 1
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Qc1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

403718-45-6

403718-45-6 structure

403718-45-6 structure

Name: Qc 1
Chemical Name: N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide
CAS Number: 403718-45-6
Molecular Formula: C₂₃H₁₆F₃N₃O₂S
Molecular Weight: 455.452
Catalog: Research Areas Metabolic Disease
Create Date: 2017-06-13 11:26:15
Modify Date: 2024-04-09 11:53:19
Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease[1][2].

Name	N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide
Synonyms	N-Benzyl-4-oxo-2-thioxo-3-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-7-quinazolinecarboxamide 7-Quinazolinecarboxamide, 1,2,3,4-tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-

Description	Qc1 is a reversible and noncompetitive threonine dehydrogenase (TDH) inhibitor. Qc1 can be used for the research of Metabolic disease[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	TDH[1]
In Vitro	Qc1 (10 μM; 2~24 hours; ES cells) shows that a substantial fraction of the total LC3 protein is in the LC3-I (cytoplasmic) form. After 16 h of TDH inhibition, most LC3 is converted to the LC3-II (lipid-modified) form, indicative of increased autophagic activity[2]. . Qc1 blocks the charging of tetrahydrofolate. Qc1 prevents threonine dehydrogenase from catabolizing threonine into acetyl-CoA and glycine[1][2].
References	[1]. Wang J, et al. Metabolic specialization of mouse embryonic stem cells. Cold Spring Harb Symp Quant Biol. 2011;76:183-193. [2]. Alexander PB, et al. Targeted killing of a mammalian cell based upon its specialized metabolic state. Proc Natl Acad Sci U S A. 2011;108(38):15828-15833.

Density	1.5±0.1 g/cm3
Molecular Formula	C₂₃H₁₆F₃N₃O₂S
Molecular Weight	455.452
Exact Mass	455.091522
PSA	98.98000
LogP	4.34
Index of Refraction	1.682

RIDADR	NONH for all modes of transport

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