Top Suppliers:I want be here
Related CAS#:
62499-27-8 817206-76-1
1986228-88-9 1639803-49-8
1240617-70-2 1601128-17-9
1602074-57-6 1592597-22-2
1646975-59-8 1987279-07-1
1993226-95-1 1597811-12-5

62499-27-8

62499-27-8 structure
62499-27-8 structure
  • Name: Gastrodin
  • Chemical Name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
  • CAS Number: 62499-27-8
  • Molecular Formula: C13H18O7
  • Molecular Weight: 286.278
  • Catalog: API Nervous system medication 2 sedative and hypnotics
  • Create Date: 2018-02-03 08:00:00
  • Modify Date: 2025-08-20 22:33:39
  • Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Name (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
Synonyms β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl
Gastrodin Hemihydrate
MFCD00272169
4-(hydroxymethyl)phenyl |A-d-glucopyranoside
Gastrodin
Gastrodin,Gastrodine
S2383_Selleck
4-(Hydroxymethyl)phenyl β-D-glucopyranoside
Gastrodine
Description Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Related Catalog
In Vitro Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1].
In Vivo Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1].
Cell Assay Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1].
Animal Admin Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1].
References

[1]. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489.
Density 1.5±0.1 g/cm3
Boiling Point 563.2±50.0 °C at 760 mmHg
Melting Point 154-157ºC
Molecular Formula C13H18O7
Molecular Weight 286.278
Flash Point 294.4±30.1 °C
Exact Mass 286.105255
PSA 119.61000
LogP -1.85
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.638
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS LZ5776885
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Chemsrc provides CAS#:62499-27-8 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 62499-27-8 | Chemsrc address: https://m.chemsrc.com/en/baike/829861.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved