62499-27-8

62499-27-8 structure

Name: Gastrodin
Chemical Name: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
CAS Number: 62499-27-8
Molecular Formula: C₁₃H₁₈O₇
Molecular Weight: 286.278
Catalog: API Nervous system medication 2 sedative and hypnotics
Create Date: 2018-02-03 08:00:00
Modify Date: 2026-06-29 18:00:38
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.

Name	(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol
Synonyms	Gastrodin HeMihydrate top quality Gastrodin NC-00723 b-D-Glucopyranoside,4-(hydroxymethyl)phenyl 4-hydroxybenzyl alcohol 4-o-bata-d-glucoside Gastrodin,Gastrodine S2383_Selleck 4-(Hydroxymethyl)phenyl β-D-glucopyranoside GASTRODIN (RG) Gastrodine Gastrodin 4-Hydroxybenzyl alcohol 4-O-bata-D-glucoside Gastrodia Root Extract Gastrodia elata extract Gastrodin from Gastrodia elata Bl Gastrodin //BP NC00723 Gastrodinium (4-HYDROXYBENZYLALCOHOL4-O-BETA-D-GLUCOPYRANO-SIDE) 4-O-BETA-D-GLUCOPYRANOSYLOXYBENZYL ALCOHOL 2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol Gastrodin 62-8 4-(Hydroxymethyl)phenyl beta-D-Glucopyranoside Gastro enterical p-(Hydroxymethyl)phenyl β-D-glucopyranoside Gastrodin CRS Gastrodin (Synthesize) 4-(β-D-Glucopyranosyloxy)benzyl alcohol Gastrodin, 10 mM in DMSO (2R,3S,4S,5R,6S)-2-HYDROXYMETHYL-6-(4-HYDROXYMETHYL-PHENOXY)-TETRAHYDRO-PYRAN-3,4,5-TRIOL (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-(hydroxymethyl)phenoxy)tetrahydro-2H-pyran-3,4,5-triol Gastrodin-RM Gastrodin(Gastrodine) β-D-Glucopyranoside, 4-(hydroxymethyl)phenyl Gastrodin Hemihydrate MFCD00272169 4-(hydroxymethyl)phenyl \|A-d-glucopyranoside Gastrodin> GASTRODIN

Description	Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Natural Products >> Phenols
In Vitro	Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1].
In Vivo	Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1].
Cell Assay	Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1].
Animal Admin	Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1].
References	[1]. Wang JW, et al. Gastrodin protects retinal ganglion cells through inhibiting microglial-mediated neuroinflammation in an acute ocular hypertension model. Int J Ophthalmol. 2017 Oct 18;10(10):1483-1489.

Density	1.5±0.1 g/cm3
Boiling Point	563.2±50.0 °C at 760 mmHg
Melting Point	154-157ºC
Molecular Formula	C₁₃H₁₈O₇
Molecular Weight	286.278
Flash Point	294.4±30.1 °C
Exact Mass	286.105255
PSA	119.61000
LogP	-1.85
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.638

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	LZ5776885

Precursor 9
64291-41-4 2280-44-6 623-05-2 1010838-90-0
572-09-8 78617-45-5 106-44-5 604-69-3
14581-78-3
DownStream 0

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