366-70-1
366-70-1 structure
- Name: Procarbazine hydrochloride
- Chemical Name: procarbazine hydrochloride
- CAS Number: 366-70-1
- Molecular Formula: C12H20ClN3O
- Molecular Weight: 257.760
- Catalog: Biochemical Inhibitor DNA damage DNA/RNA Synthesis inhibitor
- Create Date: 2018-08-31 20:19:29
- Modify Date: 2024-01-02 21:42:34
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Procarbazine Hydrochloride is an alkylating agent, with anticancer activity.
| Name | procarbazine hydrochloride |
|---|---|
| Synonyms |
N-Isopropyl-4-[(2-methylhydrazino)methyl]benzamide hydrochloride (1:1)
4-[(2-methylhydrazinyl)methyl]-N-propan-2-ylbenzamide,hydrochloride N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride MFCD00072082 Procarbazine hydrochloride 4-[(2-methylhydrazinyl)methyl]-N-(propan-2-yl)benzamide hydrochloride (1:1) benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]-, monohydrochloride Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazinyl)methyl]-, hydrochloride (1:1) Procarbazine HCl EINECS 206-678-6 p-Toluamide, N-isopropyl-α- (2-methylhydrazino)-, monohydrochloride Procarbazine (Hydrochloride) |
| Description | Procarbazine Hydrochloride is an alkylating agent, with anticancer activity. |
|---|---|
| Related Catalog | |
| In Vitro | Procarbazine Hydrochloride is an anticancer agent. Procarbazine is not cytotoxic to the LI 210 cells which lack cytochrome P-450 or monoamine oxidase activity[1]. |
| In Vivo | Procarbazine Hydrochloride (50 mg/kg, i.p.) causes micronuclei in hematopoietic cells, but does not increase the lacZ mutant frequency (MF) in bone marrow of mice, similar to that in liver, testis, spleen, kidney, and lung. Procarbazine Hydrochloride (50 mg/kg, i.p.) has positive effect on lung, bone marrow, and spleen for carcinogenesis[2]. Procarbazine (450 mg/kg) significantly decreases testicular and epididymal weight and drastically reduces haploid cells and spermatogenic arrest in hamster[3]. |
| Cell Assay | Following Procarbazine or metabolite treatment, cells are diluted to 50.000/mL in 25-cm2 culture flasks (10 mL). Every 24 h, a 0.5-mL aliquot is removed, diluted 20-fold in Hematall isotonic diluent, and the cell number determined with a Coulter Model F electronic cell counter. Counts greater than 10,000/0.5 mL are corrected for coincidence. Cells are diluted in fresh culture media when cell density exceeded 1 × 106/mL. Cultures are maintained until the aggregate cell number approached 100 × 106/mL and doubling time has returned to 12 h. Cell survival is determined using Equation A, where TD(doubling time for cells of interest) is 12 h[1]. |
| Animal Admin | Mice[2] Male MutaTM Mouse animals (7-8 weeks old) are used after 2 weeks of acclimation. In the first experiment, 18 mice are injected intraperitoneally (i.p.) with 50 mg/kg Procarbazine hydrochloride in 10 mL saline/kg and eight mice are injected with 10 mL saline/kg as the vehicle control. Six treated mice are killed 7, 14, and 28 days after treatment, and four control mice are killed 7 and 28 days after the treatment. Killing is by cervical dislocation[2]. |
| References |
| Boiling Point | 384.6ºC at 760 mmHg |
|---|---|
| Melting Point | 223ºC |
| Molecular Formula | C12H20ClN3O |
| Molecular Weight | 257.760 |
| Flash Point | 148.9ºC |
| Exact Mass | 257.129486 |
| PSA | 53.16000 |
| LogP | 3.02350 |
| Storage condition | -20°C Freezer |
| Water Solubility | >=10 g/100 mL at 21.5 ºC |
|
Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: Procarbazine Hydrochloride CAS-No.: 366-70-1 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 4) Germ cell mutagenicity (Category 2) Carcinogenicity (Category 1B) Reproductive toxicity (Category 1A) Classification according to EU Directives 67/548/EEC or 1999/45/EC Harmful if swallowed. May cause cancer. May cause harm to the unborn child. Possible risk of irreversible effects. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordDanger Hazard statement(s) H302Harmful if swallowed. H341Suspected of causing genetic defects. H350May cause cancer. H360May damage fertility or the unborn child. Precautionary statement(s) P201Obtain special instructions before use. P281Use personal protective equipment as required. P308 + P313IF exposed or concerned: Get medical advice/ attention. Supplemental Hazardnone Statements Restricted to professional users. According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R45May cause cancer. R61May cause harm to the unborn child. R22Also harmful if swallowed. R68Possible risk of irreversible effects. S-phrase(s) S36/37Wear suitable protective clothing and gloves. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S53Avoid exposure - obtain special instructions before use. Restricted to professional users. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms: N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride Formula: C12H19N3O·HCl Molecular Weight: 257,76 g/mol ComponentConcentration PROCARBAZINE HYDROCHLORIDE CAS-No.366-70-1- EC-No.206-678-6 Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Blood disorders, Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea., Exposure can cause numbness, tingling, and weakness in extremities. Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture no data available Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid exposure - obtain special instructions before use.Avoid contact with skin and eyes. Avoid inhalation of vapour or mist. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: liquid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity LD50 Oral - rat - 570 mg/kg LD50 Oral - mouse - 560 mg/kg LD50 Intravenous - rat - 350 mg/kg LD50 Subcutaneous - rat - 490 mg/kg LD50 Intraperitoneal - mouse - 699 mg/kg LD50 Intravenous - mouse - 540 mg/kg LD50 Subcutaneous - mouse - 710 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity In vitro tests showed mutagenic effects Carcinogenicity Possible human carcinogen IARC:2A - Group 2A: Probably carcinogenic to humans (PROCARBAZINE HYDROCHLORIDE) Reproductive toxicity Known human reproductive toxicant Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects InhalationMay be harmful if inhaled. May cause respiratory tract irritation. IngestionHarmful if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Signs and Symptoms of Exposure Blood disorders, Ingestion may cause gastrointestinal irritation, nausea, vomiting and diarrhoea., Exposure can cause numbness, tingling, and weakness in extremities. Additional Information RTECS: Not available Section12. ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: -IMDG: -IATA: - UN proper shipping name ADR/RID: Not dangerous goods IMDG: Not dangerous goods IATA:Not dangerous goods Transport hazard class(es) ADR/RID: -IMDG: -IATA: - Packaging group ADR/RID: -IMDG: -IATA: - Environmental hazards ADR/RID: noIMDG Marine pollutant: noIATA: no Special precautions for user no data available SECTION 15 - REGULATORY INFORMATION N/A SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS07, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H302-H341-H350-H360 |
| Precautionary Statements | P201-P280-P301 + P312 + P330-P308 + P313 |
| Hazard Codes | T |
| Risk Phrases | 45-61-22-68 |
| Safety Phrases | 53-36/37-45 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2928000090 |
| HS Code | 2928000090 |
|---|---|
| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |