78432-77-6

78432-77-6 structure

Name: Deacetyltaxol
Chemical Name: Deacetyltaxol
CAS Number: 78432-77-6
Molecular Formula: C₄₅H₄₉NO₁₃
Molecular Weight: 811.870
Catalog: Biochemical Plant extracts
Create Date: 2018-07-16 12:14:14
Modify Date: 2024-01-02 10:55:46
10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].

Name	Deacetyltaxol
Synonyms	benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 7-epi-10-deacetyltaxol b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR,bS),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester (2α,5β,7β,10β,13α)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate 7-EPI-10-DEACETYL PACLITAXEL 10-DEACETYLTAXOL 10-Desacetyl Paclitaxel (2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate 10-Desacetyltaxol Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,1 3-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)- 10-Deacetylpaclitaxel 10-DAT

Description	10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	tubulin[2]
References	[1]. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9. [2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A. [3]. Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.

Safety Phrases	24/25
HS Code	29329990

114915-18-3

~89%

78432-77-6

Literature: Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190

98-88-4

78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190

114915-14-9

78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190

197013-82-4

~9%

32981-86-5

78432-77-6

33069-62-4

Detail

Literature: Chemistry Letters, , vol. 37, # 3 p. 362 - 363

7722-84-1

33069-62-4

~98%

78432-77-6

Literature: Hauser, Inc. Patent: US5629433 A1, 1997 ;

33069-62-4

~95%

78432-77-6

Literature: Zheng, Qun Y.; Darbie, Lynn G.; Cheng, Xiaoqin; Murray, Christopher K. Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2001 - 2004

197013-82-4

~5%

78432-77-6

33069-62-4

Literature: Chemistry Letters, , vol. 37, # 3 p. 362 - 363

114915-16-1

78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190