Deacetyltaxol

Modify Date: 2024-01-02 10:55:46

Deacetyltaxol Structure
Deacetyltaxol structure
 Common Name Deacetyltaxol
CAS Number 78432-77-6 Molecular Weight 811.870
Density 1.4±0.1 g/cm3 Boiling Point 959.5±65.0 °C at 760 mmHg
Molecular Formula C45H49NO13 Melting Point 182-184ºC
MSDS N/A Flash Point 534.1±34.3 °C

 Use of Deacetyltaxol


10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].

 Names

Name Deacetyltaxol
Synonym More Synonyms

 Deacetyltaxol Biological Activity

Description 10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3].
Related Catalog
Target

tubulin[2]

References

[1]. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9.

[2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A.

[3]. Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 959.5±65.0 °C at 760 mmHg
Melting Point 182-184ºC
Molecular Formula C45H49NO13
Molecular Weight 811.870
Flash Point 534.1±34.3 °C
Exact Mass 811.320374
PSA 215.22000
LogP 6.74
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.652
Storage condition -20°C Freezer

 Safety Information

Safety Phrases 24/25
HS Code 29329990

 Synthetic Route

10-Deacetyl-7,10-bis(trichloroethoxycarbonyl)-taxol structure

10-Deacetyl-7,1...

CAS#:114915-18-3

~89%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Literature: Mangatal; Adeline; Guenard; Gueritte-Voegelein; Potier Tetrahedron, 1989 , vol. 45, # 13 p. 4177 - 4190
Benzoyl chloride structure

Benzoyl chloride

CAS#:98-88-4

~%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190
7,10-di-Troc-Docetaxel structure

7,10-di-Troc-Do...

CAS#:114915-14-9

~%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190
N/A structure

N/A

CAS#:197013-82-4

~9%

10-Deacetylbaccatin III structure

10-Deacetylbacc...

CAS#:32981-86-5

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Paclitaxel structure

Paclitaxel

CAS#:33069-62-4

Detail
Literature: Chemistry Letters, , vol. 37, # 3 p. 362 - 363
Hydrogen peroxide structure

Hydrogen peroxide

CAS#:7722-84-1

Paclitaxel structure

Paclitaxel

CAS#:33069-62-4

~98%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Literature: Hauser, Inc. Patent: US5629433 A1, 1997 ;
Paclitaxel structure

Paclitaxel

CAS#:33069-62-4

~95%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Literature: Zheng, Qun Y.; Darbie, Lynn G.; Cheng, Xiaoqin; Murray, Christopher K. Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2001 - 2004
N/A structure

N/A

CAS#:197013-82-4

~5%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Paclitaxel structure

Paclitaxel

CAS#:33069-62-4

Literature: Chemistry Letters, , vol. 37, # 3 p. 362 - 363
N-Des-t-boc-10-deacetyl-7,10-O-bis{[(2,2,2-trichloroethyl)oxy]carbonyl} Docetaxel structure

N-Des-t-boc-10-...

CAS#:114915-16-1

~%

Deacetyltaxol Structure

Deacetyltaxol

CAS#:78432-77-6

Literature: Tetrahedron, , vol. 45, # 13 p. 4177 - 4190

 Synonyms

benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
7-epi-10-deacetyltaxol
b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR*,bS*),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester
(2α,5β,7β,10β,13α)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
7-EPI-10-DEACETYL PACLITAXEL
10-DEACETYLTAXOL
10-Desacetyl Paclitaxel
(2α,5β,7β,10β,13α)-4-Acetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
10-Desacetyltaxol
Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,1 3-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
10-Deacetylpaclitaxel
10-DAT
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