34161-23-4

34161-23-4 structure

Name: Attentil
Chemical Name: fipexide hydrochloride
CAS Number: 34161-23-4
Molecular Formula: C₂₀H₂₂Cl₂N₂O₄
Molecular Weight: 425.30600
Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
Create Date: 2016-06-01 21:58:43
Modify Date: 2024-01-30 09:43:13
Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is a nootropic drug. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research[1].

Name	fipexide hydrochloride
Synonyms	1-[2-(4-CHLOROPHENOXY)ACETYL]-4-[3,4-METHYLENEDIOXYBENZYL]PIPERAZINE HYDROCHLORIDE 1-(3',4'-methylenedioxybenzyl)-4-(4-chlorophenoxyacetyl)-piperazine hydrochloride 1-(1,3-benzodioxol-5-ylmethyl)-4-[(4-chlorophenoxy)acetyl]piperazinium chloride Vigilor 1-(1,3-Benzodioxol-5-yl-methyl)-4-[(4-chlorophenoxy)acetyl]piperazine hydrochloride Attentil 1-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-2-(4-chlorophenoxy)ethanone hydrochloride BP-662

Description	Fipexide hydrochloride, a parachloro-phenossiacetic acid derivative, is a nootropic drug. Fipexide hydrochloride reduces striatal adenylate cyclase activity. Fipexide hydrochloride has positive effect on cognitive performance by dopaminergic neurotransmission. Fipexide hydrochloride is used for senile dementia research[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease
References	[1]. A Marino, et al. Fipexide improvement of cognitive functions in rat: behavioural and neurochemical studies. Pharmacol Res. Mar-Apr 1990;22(2):179-87.

Density	1.342g/cm3
Boiling Point	559.3ºC at 760 mmHg
Molecular Formula	C₂₀H₂₂Cl₂N₂O₄
Molecular Weight	425.30600
Flash Point	292.1ºC
Exact Mass	424.09600
PSA	51.24000
LogP	3.46970
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TK8220100

CHEMICAL NAME :: Piperazine, 1-(1,3-benzodioxol-5-ylmethyl)-4-((4-chlorophenoxy)ac etyl)-, monohydrochloride

CAS REGISTRY NUMBER :: 34161-23-4

LAST UPDATED :: 199009

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H21-Cl-N2-O4.Cl-H

MOLECULAR WEIGHT :: 425.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4482 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4150 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 499 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia

REFERENCE :: ACTTDZ Acta Therapeutica. (Pl. de Bastogne 8, B13, 1080 Brussels, Belgium) V.1- 1975- Volume(issue)/page/year: 11,387,1985

Hazard Codes	Xn

4122-68-3

55436-41-4

~61%

34161-23-4

Literature: Gardini, G. P.; Palla, G.; Scapini, G.; Cesaroni, M. R. Synthetic Communications, 1982 , vol. 12, # 11 p. 887 - 890

20850-43-5

34161-23-4

Literature: Gardini, G. P.; Palla, G.; Scapini, G.; Cesaroni, M. R. Synthetic Communications, 1982 , vol. 12, # 11 p. 887 - 890

Precursor 3
4122-68-3 55436-41-4 20850-43-5
DownStream 0

56-41-7	108-65-6
56-35-9	64-17-5
67-56-1	108-88-3
141-78-6	1310-73-2
13463-67-7	1333-86-4